Survival in familial pancreatic cancer

Jianguang Ji, Asta Försti, Jan Sundquist, Per Lenner, Kari Hemminki

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: Family history has been reported to be associated with an increased risk of pancreatic cancer. However, its possible influence on pancreatic cancer survival has rarely been studied, probably because of the rareness of cases in the same family. Methods: We used the nationwide Swedish Family-Cancer Database to examine the survival differences between familial and sporadic pancreatic cancers. Hazard ratios (HRs) for cause-specific and overall survival in pancreatic cancer were examined. HRs show the probability of death in the study group compared to the reference group. Results: A total of 75 familial pancreatic cancers were noted. HRs were significantly higher among offspring with an affected parent compared to those without an affected parent; for cause-specific and overall survival, the HRs were 1.44 and 1.37, respectively. Reversing the analysis and deriving HRs for parents (offspring as probands) showed that familial pancreatic cancer had a worse prognosis than sporadic cases (HR 1.37 for cause-specific and 1.28 for overall survival). The HRs were close to unity among spouses with concordant pancreatic cancer. Conclusion: The data show that survival in familial pancreatic cancer is worse than that in sporadic disease, which could be explained by genetic factors, if other confounding factors can be excluded.

Original languageEnglish
Pages (from-to)252-256
Number of pages5
JournalPancreatology
Volume8
Issue number3
DOIs
StatePublished - Jun 2008
Externally publishedYes

Keywords

  • Family history
  • Hazard ratio
  • Pancreatic cancer
  • Survival

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