Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses

Dinah Henritzi; Philipp Peter Petric; Nicola Sarah Lewis; Annika Graaf; Alberto Pessia; Elke Starick; Angele Breithaupt; Günter Strebelow; Christine Luttermann; Larissa Mareike Kristin Parker; Charlotte Schröder; Bärbel Hammerschmidt; Georg Herrler; Elisabeth große Beilage; Daniel Stadlbauer; Viviana Simon; Florian Krammer; Silke Wacheck; Stefan Pesch; Martin Schwemmle; Martin Beer; Timm Clemens Harder

doi:10.1016/j.chom.2020.07.006

Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses

Dinah Henritzi, Philipp Peter Petric, Nicola Sarah Lewis, Annika Graaf, Alberto Pessia, Elke Starick, Angele Breithaupt, Günter Strebelow, Christine Luttermann, Larissa Mareike Kristin Parker, Charlotte Schröder, Bärbel Hammerschmidt, Georg Herrler, Elisabeth große Beilage, Daniel Stadlbauer, Viviana Simon, Florian Krammer, Silke Wacheck, Stefan Pesch, Martin SchwemmleMartin Beer, Timm Clemens Harder

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52 Scopus citations

Abstract

Henritzi et al. detect in domestic pig populations in Europe Influenza A viruses with extended variability and antigenically distinct from human vaccine strains. Several isolates are resistant to human MxA and transmit by aerosol in ferrets. Building blocks of pre-pandemic influenza A viruses may be circulating in European swine populations.

Original language	English
Pages (from-to)	614-627.e6
Journal	Cell Host and Microbe
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2020.07.006
State	Published - 7 Oct 2020

Keywords

MxA
antigenic cartography
ferret model
influenza
prepandemic
surveillance
swine
zoonosis

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10.1016/j.chom.2020.07.006

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Henritzi, D., Petric, P. P., Lewis, N. S., Graaf, A., Pessia, A., Starick, E., Breithaupt, A., Strebelow, G., Luttermann, C., Parker, L. M. K., Schröder, C., Hammerschmidt, B., Herrler, G., Beilage, E. G., Stadlbauer, D., Simon, V., Krammer, F., Wacheck, S., Pesch, S., ... Harder, T. C. (2020). Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses. Cell Host and Microbe, 28(4), 614-627.e6. https://doi.org/10.1016/j.chom.2020.07.006

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title = "Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses",

abstract = "Henritzi et al. detect in domestic pig populations in Europe Influenza A viruses with extended variability and antigenically distinct from human vaccine strains. Several isolates are resistant to human MxA and transmit by aerosol in ferrets. Building blocks of pre-pandemic influenza A viruses may be circulating in European swine populations.",

keywords = "MxA, antigenic cartography, ferret model, influenza, prepandemic, surveillance, swine, zoonosis",

author = "Dinah Henritzi and Petric, {Philipp Peter} and Lewis, {Nicola Sarah} and Annika Graaf and Alberto Pessia and Elke Starick and Angele Breithaupt and G{\"u}nter Strebelow and Christine Luttermann and Parker, {Larissa Mareike Kristin} and Charlotte Schr{\"o}der and B{\"a}rbel Hammerschmidt and Georg Herrler and Beilage, {Elisabeth gro{\ss}e} and Daniel Stadlbauer and Viviana Simon and Florian Krammer and Silke Wacheck and Stefan Pesch and Martin Schwemmle and Martin Beer and Harder, {Timm Clemens}",

note = "Funding Information: We thank Aline Maksimov, Diana Parlow, Kathrin Steffen, Sina Ramcke, and Carl Sell for excellent technical assistance. We are grateful to Maria C. Berm{\'u}dez Gonz{\'a}lez, Elena Hirsch, Ralf Fernandez, and Jose Polanco for expert handling of the human blood samples. The study has been funded by grants from Ceva Sant{\'e} Animale , Dessau-Rosslau, Germany (former IDT Biologika GmbH, project Ri-0402). We thank the practicing veterinarians for submitting swine samples for influenza A virus monitoring as well as the study participants for providing plasma samples for research purposes. Work in the Krammer laboratory was supported by the National Institute of Allergy and Infectious Disease (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) contract HHSN272201400008C. The human sample collection was funded, in part, by philanthropic and institutional funds provided to the Personalized Virology Initiative (VS). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

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doi = "10.1016/j.chom.2020.07.006",

language = "English",

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Henritzi, D, Petric, PP, Lewis, NS, Graaf, A, Pessia, A, Starick, E, Breithaupt, A, Strebelow, G, Luttermann, C, Parker, LMK, Schröder, C, Hammerschmidt, B, Herrler, G, Beilage, EG, Stadlbauer, D, Simon, V, Krammer, F, Wacheck, S, Pesch, S, Schwemmle, M, Beer, M & Harder, TC 2020, 'Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses', Cell Host and Microbe, vol. 28, no. 4, pp. 614-627.e6. https://doi.org/10.1016/j.chom.2020.07.006

TY - JOUR

T1 - Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses

AU - Henritzi, Dinah

AU - Petric, Philipp Peter

AU - Lewis, Nicola Sarah

AU - Graaf, Annika

AU - Pessia, Alberto

AU - Starick, Elke

AU - Breithaupt, Angele

AU - Strebelow, Günter

AU - Luttermann, Christine

AU - Parker, Larissa Mareike Kristin

AU - Schröder, Charlotte

AU - Hammerschmidt, Bärbel

AU - Herrler, Georg

AU - Beilage, Elisabeth große

AU - Stadlbauer, Daniel

AU - Simon, Viviana

AU - Krammer, Florian

AU - Wacheck, Silke

AU - Pesch, Stefan

AU - Schwemmle, Martin

AU - Beer, Martin

AU - Harder, Timm Clemens

N1 - Funding Information: We thank Aline Maksimov, Diana Parlow, Kathrin Steffen, Sina Ramcke, and Carl Sell for excellent technical assistance. We are grateful to Maria C. Bermúdez González, Elena Hirsch, Ralf Fernandez, and Jose Polanco for expert handling of the human blood samples. The study has been funded by grants from Ceva Santé Animale , Dessau-Rosslau, Germany (former IDT Biologika GmbH, project Ri-0402). We thank the practicing veterinarians for submitting swine samples for influenza A virus monitoring as well as the study participants for providing plasma samples for research purposes. Work in the Krammer laboratory was supported by the National Institute of Allergy and Infectious Disease (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) contract HHSN272201400008C. The human sample collection was funded, in part, by philanthropic and institutional funds provided to the Personalized Virology Initiative (VS). Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020/10/7

Y1 - 2020/10/7

N2 - Henritzi et al. detect in domestic pig populations in Europe Influenza A viruses with extended variability and antigenically distinct from human vaccine strains. Several isolates are resistant to human MxA and transmit by aerosol in ferrets. Building blocks of pre-pandemic influenza A viruses may be circulating in European swine populations.

AB - Henritzi et al. detect in domestic pig populations in Europe Influenza A viruses with extended variability and antigenically distinct from human vaccine strains. Several isolates are resistant to human MxA and transmit by aerosol in ferrets. Building blocks of pre-pandemic influenza A viruses may be circulating in European swine populations.

KW - MxA

KW - antigenic cartography

KW - ferret model

KW - influenza

KW - prepandemic

KW - surveillance

KW - swine

KW - zoonosis

UR - http://www.scopus.com/inward/record.url?scp=85089370564&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2020.07.006

DO - 10.1016/j.chom.2020.07.006

M3 - Article

C2 - 32721380

AN - SCOPUS:85089370564

SN - 1931-3128

VL - 28

SP - 614-627.e6

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses

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Keywords

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