TY - JOUR
T1 - Surrogate marker of preclinical tuberculosis in human immunodeficiency virus infection
T2 - Antibodies to an 88-kDa secreted antigen of Mycobacterium tuberculosis
AU - Laal, Suman
AU - Samanich, Karen M.
AU - Sonnenberg, Michael G.
AU - Belisle, John T.
AU - O'Leary, Jeanne
AU - Simberkoff, Michael S.
AU - Zolla-Pazner, Susan
N1 - Funding Information:
Received 4 November 1996; revised 13 February 1997. Presented in part: Molecular Mechanisms in Tuberculosis, Tamarron, Colorado, 19–25 February 1995 (abstract B3-411); First National Conference on Human Retroviruses and Related Infections, Washington, DC, 12–16 December 1993 (poster 741); Fourth National Conference on Retroviruses and Opportunistic Infections, Washington, DC, 22–26 January 1997 (poster 642). Blood was obtained from all patients after informed consent was obtained. Financial support: Research Center for AIDS and HIV Infection of the Department of Veterans Affairs; NIH (AI-36984, AI-25147). Reprints or correspondence: Dr. Suman Laal, VA Medical Center, 423 E. 23rd St., Room 18123N, New York, NY 10010.
PY - 1997
Y1 - 1997
N2 - Antibodies to purified, size-fractionated secreted proteins of Mycobacterium tuberculosis in sera from patients with human immunodeficiency virus (HIV) infection and active tuberculosis (HIV/TB patients), and in stored sera obtained from the same patients prior to clinical manifestation of TB, were evaluated by ELISA, and the repertoire of antigens recognized was analyzed by immunoblotting. Compared with non-HIV/TB patients, HIV/TB patients had lower levels of anti-mycobacterial antibodies, and these were directed toward a restricted set of antigens. Antibodies to an 88-kDa secreted antigen were present in the sera of 74% of HIV/TB patients during the years (1.5-6) prior to manifestation of active, clinical tuberculosis, although only 66% were positive by the time tuberculosis was diagnosed. The presence of antibodies to the 88-kDa antigen can serve as a surrogate marker for identifying HIV-infected persons with active, subclinical disease who are at a high risk of developing clinical tuberculosis.
AB - Antibodies to purified, size-fractionated secreted proteins of Mycobacterium tuberculosis in sera from patients with human immunodeficiency virus (HIV) infection and active tuberculosis (HIV/TB patients), and in stored sera obtained from the same patients prior to clinical manifestation of TB, were evaluated by ELISA, and the repertoire of antigens recognized was analyzed by immunoblotting. Compared with non-HIV/TB patients, HIV/TB patients had lower levels of anti-mycobacterial antibodies, and these were directed toward a restricted set of antigens. Antibodies to an 88-kDa secreted antigen were present in the sera of 74% of HIV/TB patients during the years (1.5-6) prior to manifestation of active, clinical tuberculosis, although only 66% were positive by the time tuberculosis was diagnosed. The presence of antibodies to the 88-kDa antigen can serve as a surrogate marker for identifying HIV-infected persons with active, subclinical disease who are at a high risk of developing clinical tuberculosis.
UR - https://www.scopus.com/pages/publications/0030941384
U2 - 10.1086/514015
DO - 10.1086/514015
M3 - Article
C2 - 9207359
AN - SCOPUS:0030941384
SN - 0022-1899
VL - 176
SP - 133
EP - 143
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -