Surgical ventricular restoration: The RESTORE group experience

Constantine L. Athanasuleas, Gerald Buckberg, Alfred W.H. Stanley, William Siler, Vincent Dor, Marisa Di Donato, Lorenzo Menicanti, Sergio Almeida de Oliveira, Friedhelm Beyersdorf, Irving L. Kron, Hisayoshi Suma, Nicholas T. Kouchoukos, Wistar Moore, Patrick M. McCarthy, Mehmet C. Oz, Francis Fontan, Meredith L. Scott, Kevin A. Accola, Eugene H. Blackstone, Randall C. StarlingJames B. Young, John W. Kirklin, John Kern, Eric Powers, Patricia L. Cole, Eric A. Rose, Carlo Santambrogio, Protasio L. da Luz, Sergio A. de Oliveira, Taiko Horii, Takaaki Isshiki

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Congestive heart failure may be caused by late left ventricular (LV) dilation following anterior infarction. Early reperfusion prevents transmural necrosis, and makes the infarcted segment akinetic rather than dyskinetic. Surgical ventricular restoration (SVR) reduces LV volume and creates a more elliptical chamber by excluding scar in either akinetic or dyskinetic segments. The international RESTORE group applied SVR in a registry of 1198 post-infarction patients between 1998 and 2003. Early and late outcomes were examined and risk factors identified. Concomitant procedures included coronary artery bypass grafting in 95%, mitral valve repair in 22%, and mitral valve replacement in 1%. Overall 30-day mortality after SVR was 5.3% (8.7% with mitral repair vs. 4.0% without repair, p < .001) Perioperative mechanical support was uncommon (< 9%). Global systolic function improved pos toperatively, as ejection fraction increased from 29.6 ± 11.0% to 39.5 ± 12.3% (p < .001) and left ventricular end systolic volume index decreased from 80.4 ± 51.4 ml/m2 to 56.6 ± 34.3 ml/m2 (p < .001). Overall 5-year survival was 68.6 ± 2.8%, Logistic regression analysis identified EF ≤ 30%, LVESVI ≥ 80 ml/m2, advanced NYHA functional class, and age ≥75 years as risk factors for death. Five-year freedom from hospital readmission for CHF was 78%. Preoperatively, 67% of patients were class III or IV, and postoperatively 85% were class I or II. SVR improves ventricular function and is highly effective therapy in the treatment of ischemic cardiomyopathy with excellent 5-year outcome.

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalHeart Failure Reviews
Issue number4
StatePublished - Oct 2005
Externally publishedYes


  • Akinesia
  • Congestive heart failure
  • Dyskinesia
  • Ejection fraction
  • LV restoration


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