Surgical outcome of desmoid tumors: Adjuvant radiotherapy delayed the recurrence, but did not affect long-term outcomes

Seung Han Shin, Kyung Rae Ko, Samuel K. Cho, Yoon La Choi, Sung Wook Seo

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Background We retrospectively reviewed the outcomes of desmoid tumor (DT) patients treated by surgical excision. Methods Among 155 consecutive patients, 119 patients satisfied our inclusion criteria. The mean follow-up duration was 82 months. Age, gender, location, size, depth, resection margin, adjuvant radiotherapy, and excision history were analyzed for the outcomes. Results The recurrence-free survival (RFS) rates were 75% at 5 years and 72% at 10 years. Twenty-seven (93.1%) out of 29 recurrences were detected within 5 years. In multivariate analysis, positive resection margin and excision history were independently associated with the RFS. In the comparison between the propensity score matched groups, adjuvant radiotherapy was not significantly associated with the RFS. The mean time interval from surgery to recurrence was 30.0 ± 28.7 months (median, 20 months; range, 4-123 months). This interval was significantly longer for patients who received adjuvant radiotherapy than for those who received surgical resection only, both in all recurrences and in recurrences in matched cases. Conclusions Surgical excision appears to be a reliable treatment option for DTs. However, positive outcomes require a clear resection margin. Adjuvant radiotherapy may delay the recurrence of the tumor, although it seems to have no effect on the ultimate relapse rate.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalJournal of Surgical Oncology
Volume108
Issue number1
DOIs
StatePublished - Jul 2013

Keywords

  • adjuvant radiotherapy
  • desmoid tumor
  • prognostic factor
  • surgical excision

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