TY - JOUR
T1 - Surgery increases fetal plasma prostacyclin
AU - Leffler, Charles W.
AU - Hessler, Jack R.
AU - Green, Robert S.
N1 - Funding Information:
This work was done during the tenure of an Established Investiga-torship from the American Heart Association (CWL) and with funds contributed in part by the Tennessee Affiliate. The research was supported in part by NIH grant HL22639, a Grant-in-Aid from the American Heart Association with funds contributed in part by the Tennessee Affiliate, a Grant-in-Aid from the Tennessee Lung Association, and by a Biomedical Research Support Grant from the University of Tennessee College of Medicine.
PY - 1982/9
Y1 - 1982/9
N2 - Pulmonary arterial prostacyclin (as 6-keto-PGF1α) concentrations of near term, fetakl lambs and goats were determined following fetal surgery and 24, 48, and 72 hrs later. Blood gases, pH, and arterial pressure were determined also. At the end of 2.5 hrs of surgery including exteriorization of the uterus and fetal thorocotomy, pulmonary arterial concentrations of 6-keto-PGF1α was 948 ± 92 (SEM) pg/ml of blood. Twenty-four hrs later it had fallen to 435 ± 92 pg/ml and remained constant for the duration of monitoring. Maternal arterial 6-keto-PGF1α concentration was much lower (105 ± 20 pg/ml of blood). No significance changes in fetal PaO2, PaCO2, pH, or arterial pressure were observed, although PaCO2 appeared to be elevated and pH reduced following surgery. These values normalized within 24 hrs. We conclude that surgical perturbation increases fetal arterial prostacyclin concentration. Increased prostacyclin levels are transient, reaching stable values within 24 hrs following completion of extensive surgery.
AB - Pulmonary arterial prostacyclin (as 6-keto-PGF1α) concentrations of near term, fetakl lambs and goats were determined following fetal surgery and 24, 48, and 72 hrs later. Blood gases, pH, and arterial pressure were determined also. At the end of 2.5 hrs of surgery including exteriorization of the uterus and fetal thorocotomy, pulmonary arterial concentrations of 6-keto-PGF1α was 948 ± 92 (SEM) pg/ml of blood. Twenty-four hrs later it had fallen to 435 ± 92 pg/ml and remained constant for the duration of monitoring. Maternal arterial 6-keto-PGF1α concentration was much lower (105 ± 20 pg/ml of blood). No significance changes in fetal PaO2, PaCO2, pH, or arterial pressure were observed, although PaCO2 appeared to be elevated and pH reduced following surgery. These values normalized within 24 hrs. We conclude that surgical perturbation increases fetal arterial prostacyclin concentration. Increased prostacyclin levels are transient, reaching stable values within 24 hrs following completion of extensive surgery.
UR - http://www.scopus.com/inward/record.url?scp=0020434774&partnerID=8YFLogxK
U2 - 10.1016/0090-6980(82)90165-4
DO - 10.1016/0090-6980(82)90165-4
M3 - Article
C2 - 6760254
AN - SCOPUS:0020434774
SN - 0090-6980
VL - 24
SP - 387
EP - 396
JO - Prostaglandins
JF - Prostaglandins
IS - 3
ER -