Surgery increases fetal plasma prostacyclin

Charles W. Leffler, Jack R. Hessler, Robert S. Green

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Pulmonary arterial prostacyclin (as 6-keto-PGF) concentrations of near term, fetakl lambs and goats were determined following fetal surgery and 24, 48, and 72 hrs later. Blood gases, pH, and arterial pressure were determined also. At the end of 2.5 hrs of surgery including exteriorization of the uterus and fetal thorocotomy, pulmonary arterial concentrations of 6-keto-PGF was 948 ± 92 (SEM) pg/ml of blood. Twenty-four hrs later it had fallen to 435 ± 92 pg/ml and remained constant for the duration of monitoring. Maternal arterial 6-keto-PGF concentration was much lower (105 ± 20 pg/ml of blood). No significance changes in fetal PaO2, PaCO2, pH, or arterial pressure were observed, although PaCO2 appeared to be elevated and pH reduced following surgery. These values normalized within 24 hrs. We conclude that surgical perturbation increases fetal arterial prostacyclin concentration. Increased prostacyclin levels are transient, reaching stable values within 24 hrs following completion of extensive surgery.

Original languageEnglish
Pages (from-to)387-396
Number of pages10
Issue number3
StatePublished - Sep 1982
Externally publishedYes


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