TY - JOUR
T1 - Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly
AU - Apostolova, Liana G.
AU - Thompson, Paul M.
AU - Rogers, Steve A.
AU - Dinov, Ivo D.
AU - Zoumalan, Charleen
AU - Steiner, Calen A.
AU - Siu, Erin
AU - Green, Amity E.
AU - Small, Gary W.
AU - Toga, Arthur W.
AU - Cummings, Jeffrey L.
AU - Phelps, Michael E.
AU - Silverman, Daniel H.
N1 - Funding Information:
Acknowledgments. This study was generously supported by NIA K23 AG026803 (jointly sponsored by NIA, AFAR, The John A. Hartford Foundation, the Atlantic Philanthropies, the Starr Foundation, and an anonymous donor; to LGA), NIA P50 AG16570 (to JLC, LGA and PMT); NIBIB EB01651, NLM LM05639, NCRR RR019771 (to PMT); NIH/NIMH R01 MH071940, NIH/NCRR P41 RR013642 and NIH U54 RR021813 (to AWT and PMT); NIH PO1-AG024831, AG 13308, P50 AG16570, MH/AG58156, MH52453, AG10123, MO1-RR00865 (to GWS), the Department of Energy (DOE contract DE-FC03-87-ER60615), General Clinical Research Centers Program, the Rotary CART Fund; the Alzheimer's Association; the Fran and Ray Stark Foundation Fund for Alzheimer's Disease Research; the Ahmanson Foundation; the Larry L. Hillblom Foundation; the Lovelace Foundation, the Judith Olenick Elgart Fund for Research on Brain Aging, the John D. French Foundation for Alzheimer's Research, and the Tamkin Foundation (to GWS).
PY - 2010/4
Y1 - 2010/4
N2 - Purpose: The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. Procedures: Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4±0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-PET scan (interval 21.7±3.7 months), baseline structural 3T magnetic resonance (MR) imaging, and apolipoprotein E4 genotyping. Cortical PET metabolic changes were analyzed in 3-D using the cortical pattern matching technique. Results: Baseline vs. follow-up whole-group comparison revealed significant metabolic decline bilaterally in the posterior temporal, parietal, and occipital lobes and the left lateral frontal cortex. The declining group demonstrated 10-15% decline in bilateral posterior cingulate/precuneus, posterior temporal, parietal, and occipital cortices. The cognitively stable group showed 2.5-5% similarly distributed decline. ApoE4-positive individuals underwent 5-15% metabolic decline in the posterior association cortices. Conclusions: Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group.
AB - Purpose: The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. Procedures: Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4±0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-PET scan (interval 21.7±3.7 months), baseline structural 3T magnetic resonance (MR) imaging, and apolipoprotein E4 genotyping. Cortical PET metabolic changes were analyzed in 3-D using the cortical pattern matching technique. Results: Baseline vs. follow-up whole-group comparison revealed significant metabolic decline bilaterally in the posterior temporal, parietal, and occipital lobes and the left lateral frontal cortex. The declining group demonstrated 10-15% decline in bilateral posterior cingulate/precuneus, posterior temporal, parietal, and occipital cortices. The cognitively stable group showed 2.5-5% similarly distributed decline. ApoE4-positive individuals underwent 5-15% metabolic decline in the posterior association cortices. Conclusions: Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group.
KW - Alzheimer's disease (AD)
KW - Cognitive decline
KW - Mild cognitive impairment (MCI)
KW - Positron emission tomography (PET)
UR - https://www.scopus.com/pages/publications/77953536045
U2 - 10.1007/s11307-009-0247-7
DO - 10.1007/s11307-009-0247-7
M3 - Article
C2 - 19636640
AN - SCOPUS:77953536045
SN - 1536-1632
VL - 12
SP - 218
EP - 224
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
IS - 2
ER -