Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward

Alexandra G. DiFeliceantonio, Géraldine Coppin, Lionel Rigoux, Sharmili Edwin Thanarajah, Alain Dagher, Marc Tittgemeyer, Dana M. Small

Research output: Contribution to journalArticlepeer-review

166 Scopus citations

Abstract

Post-ingestive signals conveying information about the nutritive properties of food are critical for regulating ingestive behavior. Here, using an auction task concomitant to fMRI scanning, we demonstrate that participants are willing to pay more for fat + carbohydrate compared with equally familiar, liked, and caloric fat or carbohydrate foods and that this potentiated reward is associated with response in areas critical for reward valuation, including the dorsal striatum and mediodorsal thalamus. We also show that individuals are better able to estimate the energy density of fat compared with carbohydrate and fat + carbohydrate foods, an effect associated with functional connectivity between visual (fusiform gyrus) and valuation (ventromedial prefrontal cortex) areas. These results provide the first demonstration that foods high in fat and carbohydrate are, calorie for calorie, valued more than foods containing only fat or carbohydrate and that this effect is associated with greater recruitment of central reward circuits.

Original languageEnglish
Pages (from-to)33-44.e3
JournalCell Metabolism
Volume28
Issue number1
DOIs
StatePublished - 3 Jul 2018
Externally publishedYes

Keywords

  • carbohydrate
  • dopamine
  • fMRI
  • fat
  • food reward
  • gut-brain axis
  • neural circuits
  • reinforcement
  • striatum
  • value

Fingerprint

Dive into the research topics of 'Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward'. Together they form a unique fingerprint.

Cite this