Suppressor of cytokine signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex

Keyphrases

• Suppressor of Cytokine Signaling 3 (SOCS3) 100%
• Interleukin-1 Signaling 100%
• TAK1 100%
• TNF Receptor Associated Factor 6 100%
• Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) 60%
• Interleukin-1β 50%
• Nuclear factor-B 40%
• Ubiquitination 20%
• Autoimmunity 10%
• Inflammation 10%
• Overexpression 10%
• Myeloid Differentiation Factor 88 (MyD88) 10%
• Catalytic Activity 10%
• Co-immunoprecipitation (co-IP) 10%
• Signaling Molecules 10%
• Activation Mechanism 10%
• Signal Transduction 10%
• ERK Kinase 10%
• IL-1R 10%
• TRAF6 Ubiquitination 10%
• Signaling Complex 10%
• ERK MAPK 10%
• IL-1 Signaling 10%
• Ubiquitin Modification 10%
• MAP3K 10%
• TAK1 Signaling 10%

Biochemistry, Genetics and Molecular Biology

• Cytokine 100%
• Interleukin-1 100%
• TNF Receptor Associated Factor 100%
• TRAF6 70%
• Kinase 40%
• Phosphotransferase 40%
• Complement Factor B 40%
• Mitogen-Activated Protein Kinase 40%
• Ubiquitination 30%
• Transcription 20%
• Autoimmunity 10%
• Signal Transduction 10%
• Downregulation 10%
• Ubiquitin 10%
• Enzymatic Activity 10%

Neuroscience

• Interleukin 1 100%
• Tumor Necrosis Factor Receptor Associated Factor 6 100%
• Suppressor of Cytokine Signaling 3 100%
• Kinase 40%
• Mitogen-Activated Protein Kinase 40%
• Nuclear Factor 40%
• Alternative Complement Pathway C3 C5 Convertase 40%
• Ubiquitination 30%
• Ubiquitin 10%
• Signal Transduction 10%