Suppression of malignancy by cell fusion

Henry Harris; O. J. Miller; G. Klein; P. Worst; T. Tachibana

doi:10.1038/223363a0

Suppression of malignancy by cell fusion

Henry Harris, O. J. Miller, G. Klein, P. Worst, T. Tachibana

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Abstract

Malignancy can be suppressed when malignant cells are fused with certain non-malignant ones. The hybrid cells derived from such fusions give rise to segregants in which a loss of chromosomes is associated with reversion to malignancy. The expression of histo-compatibility antigens can also be suppressed when cells bearing these antigens are fused with others that express them poorly.

Original language	English
Pages (from-to)	363-368
Number of pages	6
Journal	Nature
Volume	223
Issue number	5204
DOIs	https://doi.org/10.1038/223363a0
State	Published - 1969
Externally published	Yes

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title = "Suppression of malignancy by cell fusion",

abstract = "Malignancy can be suppressed when malignant cells are fused with certain non-malignant ones. The hybrid cells derived from such fusions give rise to segregants in which a loss of chromosomes is associated with reversion to malignancy. The expression of histo-compatibility antigens can also be suppressed when cells bearing these antigens are fused with others that express them poorly.",

author = "Henry Harris and Miller, {O. J.} and G. Klein and P. Worst and T. Tachibana",

year = "1969",

doi = "10.1038/223363a0",

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journal = "Nature",

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T1 - Suppression of malignancy by cell fusion

AU - Harris, Henry

AU - Miller, O. J.

AU - Klein, G.

AU - Worst, P.

AU - Tachibana, T.

PY - 1969

Y1 - 1969

N2 - Malignancy can be suppressed when malignant cells are fused with certain non-malignant ones. The hybrid cells derived from such fusions give rise to segregants in which a loss of chromosomes is associated with reversion to malignancy. The expression of histo-compatibility antigens can also be suppressed when cells bearing these antigens are fused with others that express them poorly.

AB - Malignancy can be suppressed when malignant cells are fused with certain non-malignant ones. The hybrid cells derived from such fusions give rise to segregants in which a loss of chromosomes is associated with reversion to malignancy. The expression of histo-compatibility antigens can also be suppressed when cells bearing these antigens are fused with others that express them poorly.

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U2 - 10.1038/223363a0

DO - 10.1038/223363a0

M3 - Article

C2 - 5387828

AN - SCOPUS:0014692015

SN - 0028-0836

VL - 223

SP - 363

EP - 368

JO - Nature

JF - Nature

IS - 5204

ER -

Suppression of malignancy by cell fusion

Abstract

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