Superinfection of EBV-carrying lines with Herpes virus papio (HVP): Induction of early antigen (EA) and inhibition of cellular DNA synthesis

Michael Steinitz, George Klein

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

An Epstein-Barr virus (EBV) related herpes virus H. papio (HVP) derived from 9B cell line was shown to inhibit the DNA synthesis in B-cell mitogen stimulated human lymphocytes, in B95-8 virus exposed human lymphocytes, and the DNA metabolism of EBV-receptor positive cell lines. The inhibition could be abolished by a Burkitt serum known to have a high anti-EBV titer. Similar inhibition activities were shown for P3HR-1 virus. The relationship between the inability to immortalize normal cells, the ability to induce early antigen (EA) in certain cell lines and the DNA inhibitory effect of both 9B and P3HR-1 viruses is discussed.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalEuropean Journal of Cancer (1965)
Volume15
Issue number2
DOIs
StatePublished - Feb 1979
Externally publishedYes

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