Superantigens in dermatology

Edgar S. MacIas; Frederick A. Pereira; William Rietkerk; Bijan Safai

doi:10.1016/j.jaad.2010.03.044

Superantigens in dermatology

Edgar S. MacIas
, Frederick A. Pereira
, William Rietkerk
, Bijan Safai

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.

Original language	English
Pages (from-to)	455-472
Number of pages	18
Journal	Journal of the American Academy of Dermatology
Volume	64
Issue number	3
DOIs	https://doi.org/10.1016/j.jaad.2010.03.044
State	Published - Mar 2011

Keywords

Kawasaki disease
bacterial toxins
superantigens
toxic shock syndrome

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10.1016/j.jaad.2010.03.044

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title = "Superantigens in dermatology",

abstract = "Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.",

keywords = "Kawasaki disease, bacterial toxins, superantigens, toxic shock syndrome",

author = "MacIas, \{Edgar S.\} and Pereira, \{Frederick A.\} and William Rietkerk and Bijan Safai",

year = "2011",

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doi = "10.1016/j.jaad.2010.03.044",

language = "English",

volume = "64",

pages = "455--472",

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AU - MacIas, Edgar S.

AU - Pereira, Frederick A.

AU - Rietkerk, William

AU - Safai, Bijan

PY - 2011/3

Y1 - 2011/3

N2 - Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.

AB - Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.

KW - Kawasaki disease

KW - bacterial toxins

KW - superantigens

KW - toxic shock syndrome

UR - https://www.scopus.com/pages/publications/79951562657

U2 - 10.1016/j.jaad.2010.03.044

DO - 10.1016/j.jaad.2010.03.044

M3 - Review article

C2 - 21315950

AN - SCOPUS:79951562657

SN - 0190-9622

VL - 64

SP - 455

EP - 472

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 3

ER -

Superantigens in dermatology

Abstract

Keywords

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