Superantigens in dermatology

Edgar S. MacIas, Frederick A. Pereira, William Rietkerk, Bijan Safai

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.

Original languageEnglish
Pages (from-to)455-472
Number of pages18
JournalJournal of the American Academy of Dermatology
Issue number3
StatePublished - Mar 2011


  • Kawasaki disease
  • bacterial toxins
  • superantigens
  • toxic shock syndrome


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