Superantigen-activated T cells redirected by a bispecific antibody inhibit vesicular stomatitis virus replication in vitro and in vivo

Ana Fernandez-Sesma, Richard W. Peluso, Xu Bai, Jerome L. Schulman, David E. Levy, Thomas M. Moran

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    A bispecific Ab (BsAb) that binds the TCR on T cells and the G protein of the vesicular stomatitis virus (VSV) can redirect staphylococcal enterotoxin B (SEB)-activated T cells to kill VSV-infected cells and to inhibit VSV replication in vitro. Inhibition of virus replication in our system is dependent upon the specificity of the Ab for the viral protein. IFN-γ does not play a very important role in this phenomenon, which is mainly mediated by the release of Pfp from CD8+ T cells. We have used a Stat1 knockout mouse model in which VSV infection is lethal. Infusion of staphylococcal enterotoxin-activated B T cells and bispecific Ab significantly slowed virus progression and prolonged the survival of VSV- infected Stat1 knockout mice in vivo.

    Original languageEnglish
    Pages (from-to)1841-1849
    Number of pages9
    JournalJournal of Immunology
    Volume160
    Issue number4
    StatePublished - 15 Feb 1998

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