[3H] dopamine uptake by platelet storage granules in Parkinson's disease

J. M. Rabey, H. Shabtai, E. Graff, Z. Oberman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

[3H] Dopamine (DA) uptake by platelet storage granules was determined in 10 never-treated patients with Parkinson's disease (PD) (in 6 of them, also after 6 months of levodopa treatment), in 18 long-term levodopa-treated patients and in 15 age-matched normal controls. Maximum velocity (Vmax) of DA uptake was significantly lower in the group of never-treated PD subjects compared to healthy controls (P<0.001) and also lower compared to the PD long-term treated patients (P<0.025). The Vmax of PD never-treated changed after submitting the patients to 6 months treatment (P<0.025) and became similar to the Vmax in the treated group. The apparent Michaelis constant (Km) of DA uptake in PD never-treated was also significantly different from controls (P<0.005) and also different (but not significantly) from PD "long-term" treated patients. Decreased DA uptake by platelet storage granules in PD may reflect a generalized defect of dopaminergic cells with an impairment in the vesicularization of DA which may contribute to the symptomatology of this motor disease.

Original languageEnglish
Pages (from-to)1753-1759
Number of pages7
JournalLife Sciences
Volume53
Issue number23
DOIs
StatePublished - 1993
Externally publishedYes

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