Sudden death of a young adult with coronary artery vasculitis, coronary aneurysms, parvovirus B19 infection and Kawasaki disease

Stefan Flossdorf, Karl Heinz Schiwy-Bochat, Daniela Teifel, Jochen W.U. Fries, Markus A. Rothschild

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We present a case of a 20-year-old man who suffered from Kawasaki disease (KD) associated with a florid parvovirus infection, and who died suddenly from thrombotic occlusion of the coronary arteries. The autopsy revealed several aneurysms of the coronary arteries, a chronic vasculitis and a myofibroblast proliferation leading to focal luminal narrowing. The inflammatory response as well as the detection of the viral particles by PCR in blood and in the lesional tissue demonstrated a possible cause by Parvovirus infection. The expression of endoglin on endothelial cells of neoangiogenesis indicates the involvement of the TGF-beta pathway, necessary for maintaining chronic inflammation. In addition, a possible connection between the intake of methylphenidate, arteritis and a possible pre-existing heart disease must be discussed. Furthermore, KD must also be considered as a cause of sudden death in the adult population.

Original languageEnglish
Pages (from-to)498-503
Number of pages6
JournalForensic Science, Medicine, and Pathology
Volume16
Issue number3
DOIs
StatePublished - 1 Sep 2020
Externally publishedYes

Keywords

  • Adult
  • Coronary artery aneurysm
  • Endoglin
  • Kawasaki disease
  • Methylphenidat
  • Parvovirus

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