Successful treatment of extramammary Paget's disease with imiquimod.

Zheng Qian, Nathalie C. Zeitoun, Sherry Shieh, Thomas Helm, Allan R. Oseroff

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Extramammary Paget's Disease (EMPD) is an uncommon neoplasm found in the genital, anorectal, or axillary area. Surgical excision is considered the standard treatment, although possible loss of tissue function and disease recurrence are seen. Other treatment modalities such as radiotherapy, topical chemotherapy, and photodynamic therapy are associated with varying degrees of effectiveness, but the search for an effective, safe treatment with minimal side effects proves to be challenging. We report a case where complete clinical and histological resolution of non-invasive EMPD of the penis was achieved with minimal adverse effects after six weeks of imiquimod (Aldara) application. As an immune system modifier that stimulates cytokine and interferon production, imiquimod may be a useful alternative or adjuvant in the treatment of EMPD.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalJournal of Drugs in Dermatology
Volume2
Issue number1
StatePublished - Jan 2003
Externally publishedYes

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