Successful transition to buprenorphine in a patient with methadone-induced torsades de pointes

Jason Levi Esses; Jonathan Rosman; Lien Thanh Do; Paul Schweitzer; Sam Hanon

doi:10.1007/s10840-008-9280-8

Successful transition to buprenorphine in a patient with methadone-induced torsades de pointes

Jason Levi Esses, Jonathan Rosman, Lien Thanh Do, Paul Schweitzer, Sam Hanon

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A 56-year-old-man presented with syncope and torsades de pointes secondary to methadone-induced QT prolongation. After transition from methadone to buprenorphine, a partial μ-opiate-receptor agonist and a κ-opiate- receptor antagonist, the QT normalized and ventricular arrhythmias resolved. Buprenorphine should be used for opiate dependence and chronic pain in patients with methadone-induced QT prolongation and as first line therapy in patients with risk factors for torsades de pointes.

Original language	English
Pages (from-to)	117-119
Number of pages	3
Journal	Journal of Interventional Cardiac Electrophysiology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1007/s10840-008-9280-8
State	Published - Nov 2008
Externally published	Yes

Keywords

Buprenorphine
Methadone
Prolonged QT
Torsades de pointes

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10.1007/s10840-008-9280-8

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abstract = "A 56-year-old-man presented with syncope and torsades de pointes secondary to methadone-induced QT prolongation. After transition from methadone to buprenorphine, a partial μ-opiate-receptor agonist and a κ-opiate- receptor antagonist, the QT normalized and ventricular arrhythmias resolved. Buprenorphine should be used for opiate dependence and chronic pain in patients with methadone-induced QT prolongation and as first line therapy in patients with risk factors for torsades de pointes.",

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AU - Esses, Jason Levi

AU - Rosman, Jonathan

AU - Do, Lien Thanh

AU - Schweitzer, Paul

AU - Hanon, Sam

PY - 2008/11

Y1 - 2008/11

N2 - A 56-year-old-man presented with syncope and torsades de pointes secondary to methadone-induced QT prolongation. After transition from methadone to buprenorphine, a partial μ-opiate-receptor agonist and a κ-opiate- receptor antagonist, the QT normalized and ventricular arrhythmias resolved. Buprenorphine should be used for opiate dependence and chronic pain in patients with methadone-induced QT prolongation and as first line therapy in patients with risk factors for torsades de pointes.

AB - A 56-year-old-man presented with syncope and torsades de pointes secondary to methadone-induced QT prolongation. After transition from methadone to buprenorphine, a partial μ-opiate-receptor agonist and a κ-opiate- receptor antagonist, the QT normalized and ventricular arrhythmias resolved. Buprenorphine should be used for opiate dependence and chronic pain in patients with methadone-induced QT prolongation and as first line therapy in patients with risk factors for torsades de pointes.

KW - Buprenorphine

KW - Methadone

KW - Prolonged QT

KW - Torsades de pointes

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SN - 1383-875X

IS - 2

ER -

Successful transition to buprenorphine in a patient with methadone-induced torsades de pointes

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Keywords

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