A 56-year-old-man presented with syncope and torsades de pointes secondary to methadone-induced QT prolongation. After transition from methadone to buprenorphine, a partial μ-opiate-receptor agonist and a κ-opiate- receptor antagonist, the QT normalized and ventricular arrhythmias resolved. Buprenorphine should be used for opiate dependence and chronic pain in patients with methadone-induced QT prolongation and as first line therapy in patients with risk factors for torsades de pointes.
|Number of pages||3|
|Journal||Journal of Interventional Cardiac Electrophysiology|
|State||Published - Nov 2008|
- Prolonged QT
- Torsades de pointes