Successful monozygotic twin pregnancy fathered by a male 46,XY true hermaphrodite

Johnny S. Younis, Orit Radin, Hedviga Kerner, Moshe Ben-Ami

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This report presents an unusual case of absolute non-obstructive azoospermia revealed to be a male 46,XY true hermaphrodite who was successfully treated to father healthy monozygotic twins. A 27-year-old infertile male with non-obstructive azoospermia previously underwent an unsuccessful testicular sperm extraction procedure and refused donor sperm insemination. Revising the patient's old records revealed that he was born with ambiguous genitalia. He had a 46,XY karyotype and was raised as a male. During childhood he underwent ambiguous genitalia reconstruction, right orchiopexy and left salpingo-oophorectomy that revealed a gonadoblastoma. A new treatment was employed performing testicular fine needle aspiration leading successfully to a monozygotic twin pregnancy. As far as is known, this is the first reported case of healthy twins fathered by a male 46,XY true hermaphrodite.

Original languageEnglish
Pages (from-to)80-82
Number of pages3
JournalReproductive BioMedicine Online
Volume22
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

Keywords

  • Gonadoblastoma
  • Monozygotic twin
  • Non-obstructive azoospermia
  • True hermaphrodite
  • Twin pregnancy

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