Successful arterial substitution with modified human umbilical vein

H. Dardik, I. I. Dardik

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Human umbilical veins were prepared as vascular grafts by tanning with dialdehyde starch or glutaraldehyde and by structural reinforcement with an outer polyester fiber mesh. These grafts were implanted in baboons in the aortoiliac position for periods of 3 days to 9 months. There was no aneurysm formation and there was an excellent maintenance of patency as well as function. Histologic evaluation of the graft materials showed a dense collagen layer within the encircling polyester fiber mesh. A multicellular subintimal layer formed a discrete inner capsule. The inflammatory response within the umbilical component was insignificant. There was no evidence of rejection. This study suggests that the modified umbilical vein can serve as a satisfactory blood conduit. Experience with three short term clinical implants supports the applicability and potential for this new vascular graft.

Original languageEnglish
Pages (from-to)252-258
Number of pages7
JournalAnnals of Surgery
Volume183
Issue number3
DOIs
StatePublished - 1976
Externally publishedYes

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