Subthalamic stimulation differentially modulates declarative and nondeclarative memory

Thomas D. Hälbig; Doreen Gruber; Ute A. Kopp; Peter Scherer; Gerd Helge Schneider; Thomas Trottenberg; Guy Arnold; Andreas Kupsch

doi:10.1097/00001756-200403010-00031

Subthalamic stimulation differentially modulates declarative and nondeclarative memory

Thomas D. Hälbig, Doreen Gruber, Ute A. Kopp, Peter Scherer, Gerd Helge Schneider, Thomas Trottenberg, Guy Arnold, Andreas Kupsch

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Declarative memory has been reported to rely on the medial temporal lobe system, whereas non-declarative memory depends on basal ganglia structures. We investigated the functional role of the subthalamic nucleus (STN), a structure closely connected with the basal ganglia for both types of memory. Via deep brain high frequency stimulation (DBS) we manipulated neural activity of the STN in humans. We found that DBS-STN differentially modulated memory performance: declarative memory was impaired, whereas non-declarative memory was improved in the presence of STN-DBS indicating a specific role of the STN in the activation of memory systems.

Original language	English
Pages (from-to)	539-543
Number of pages	5
Journal	NeuroReport
Volume	15
Issue number	3
DOIs	https://doi.org/10.1097/00001756-200403010-00031
State	Published - Mar 2004

Keywords

Basal ganglia
Declarative
High frequency deep brain stimulation
Long-term memory
Non-declarative
Parkinson's disease

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10.1097/00001756-200403010-00031

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abstract = "Declarative memory has been reported to rely on the medial temporal lobe system, whereas non-declarative memory depends on basal ganglia structures. We investigated the functional role of the subthalamic nucleus (STN), a structure closely connected with the basal ganglia for both types of memory. Via deep brain high frequency stimulation (DBS) we manipulated neural activity of the STN in humans. We found that DBS-STN differentially modulated memory performance: declarative memory was impaired, whereas non-declarative memory was improved in the presence of STN-DBS indicating a specific role of the STN in the activation of memory systems.",

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AU - Hälbig, Thomas D.

AU - Gruber, Doreen

AU - Kopp, Ute A.

AU - Scherer, Peter

AU - Schneider, Gerd Helge

AU - Trottenberg, Thomas

AU - Arnold, Guy

AU - Kupsch, Andreas

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AB - Declarative memory has been reported to rely on the medial temporal lobe system, whereas non-declarative memory depends on basal ganglia structures. We investigated the functional role of the subthalamic nucleus (STN), a structure closely connected with the basal ganglia for both types of memory. Via deep brain high frequency stimulation (DBS) we manipulated neural activity of the STN in humans. We found that DBS-STN differentially modulated memory performance: declarative memory was impaired, whereas non-declarative memory was improved in the presence of STN-DBS indicating a specific role of the STN in the activation of memory systems.

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KW - Declarative

KW - High frequency deep brain stimulation

KW - Long-term memory

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Subthalamic stimulation differentially modulates declarative and nondeclarative memory

Abstract

Keywords

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