Subthalamic stimulation differentially modulates declarative and nondeclarative memory

Thomas D. Hälbig, Doreen Gruber, Ute A. Kopp, Peter Scherer, Gerd Helge Schneider, Thomas Trottenberg, Guy Arnold, Andreas Kupsch

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Declarative memory has been reported to rely on the medial temporal lobe system, whereas non-declarative memory depends on basal ganglia structures. We investigated the functional role of the subthalamic nucleus (STN), a structure closely connected with the basal ganglia for both types of memory. Via deep brain high frequency stimulation (DBS) we manipulated neural activity of the STN in humans. We found that DBS-STN differentially modulated memory performance: declarative memory was impaired, whereas non-declarative memory was improved in the presence of STN-DBS indicating a specific role of the STN in the activation of memory systems.

Original languageEnglish
Pages (from-to)539-543
Number of pages5
Issue number3
StatePublished - Mar 2004


  • Basal ganglia
  • Declarative
  • High frequency deep brain stimulation
  • Long-term memory
  • Non-declarative
  • Parkinson's disease


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