@article{bfed7511034b49f2a9359b5fdf8a339a,
title = "Substrate interaction inhibits γ-secretase production of amyloid-β peptides",
abstract = "Combining NMR, mass spectrometry, AlphaLISA and cell assays, we discovered a compound C1 that binds C-terminal juxtamembrane lysines at the transmembrane domain of the amyloid precursor protein (APPTM) and inhibits γ-secretase production of amyloid-β with μM IC50. Our work suggests that targeting APPTM is a novel and viable strategy in AD drug discovery.",
author = "Jing Zhao and Yuanyuan Xiao and Xinyue Liu and Soohyun Kim and Xianzhong Wu and Marilia Barros and Ran Zhuang and Xuben Hou and Yingkai Zhang and Robakis, \{Nikolaos K.\} and Li, \{Yue Ming\} and Dordick, \{Jonathan S.\} and Iban Ubarretxena-Belandia and Chunyu Wang",
note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry.",
year = "2020",
month = feb,
day = "28",
doi = "10.1039/c9cc09170j",
language = "English",
volume = "56",
pages = "2578--2581",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "17",
}