TY - JOUR
T1 - Substitutions T200A and E227A in the hemagglutinin of pandemic 2009 influenza a virus increase lethality but decrease transmission
AU - Martínez-Romero, Carles
AU - de Vries, Erik
AU - Belicha-Villanueva, Alan
AU - Mena, Ignacio
AU - Tscherne, Donna M.
AU - Gillespie, Virginia L.
AU - Albrecht, Randy A.
AU - de Haan, Cornelis A.M.
AU - García-Sastre, Adolfo
PY - 2013/6
Y1 - 2013/6
N2 - We report that swine influenza virus-like substitutions T200A and E227A in the hemagglutinin (HA) of the 2009 pandemic influenza virus alter its pathogenesis and transmission. Viral replication is increased in mammalian cells. Infected mice show increased disease as measured by weight loss and lethality. Transmission in ferrets is decreased in the presence of both substitutions, suggesting that amino acids 200T and 227E are adaptive changes in the HA of swine origin influenza viruses associated with increased transmission and decreased pathogenesis.
AB - We report that swine influenza virus-like substitutions T200A and E227A in the hemagglutinin (HA) of the 2009 pandemic influenza virus alter its pathogenesis and transmission. Viral replication is increased in mammalian cells. Infected mice show increased disease as measured by weight loss and lethality. Transmission in ferrets is decreased in the presence of both substitutions, suggesting that amino acids 200T and 227E are adaptive changes in the HA of swine origin influenza viruses associated with increased transmission and decreased pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=84878166799&partnerID=8YFLogxK
U2 - 10.1128/JVI.00262-13
DO - 10.1128/JVI.00262-13
M3 - Article
C2 - 23536663
AN - SCOPUS:84878166799
SN - 0022-538X
VL - 87
SP - 6507
EP - 6511
JO - Journal of Virology
JF - Journal of Virology
IS - 11
ER -