TY - JOUR
T1 - SUBSTANCE P INCREASES HYPOTHALAMIC BLOOD FLOW VIA AN INDIRECT ADRENERGIC‐CHOLINERGIC INTERACTION
AU - KLUGMAN, K. P.
AU - LEMBECK, F.
AU - MARKOWITZ, S.
AU - MITCHELL, G.
AU - ROSENDORFF, C.
PY - 1980/2
Y1 - 1980/2
N2 - Hypothalamic blood flow (HBF) was measured in conscious rabbits by the 133xenon washout technique. Substance P in a dose of 50 or 500 ng increases HBF while 5 ng is without effect. Cholinoceptor blockade, with either atropine or mecamylamine abolishes the vasodilator effect of substance P. Chemical sympathectomy of the hypothalamus with 6‐hydroxydopamine, or adrenoceptor blockade with either propranolol or phenoxybenzamine abolishes the effect of substance P on HBF. Destruction of the intracerebral noradrenergic pathway (INP), or blockade of its vasodilator action, with barbiturate or bicarbonate, likewise prevent the vasodilator action of substance P. These results suggest that substance P may cause an increase in HBF via the release of endogenous acetylcholine, which in turn stimulates the INP. 1980 British Pharmacological Society
AB - Hypothalamic blood flow (HBF) was measured in conscious rabbits by the 133xenon washout technique. Substance P in a dose of 50 or 500 ng increases HBF while 5 ng is without effect. Cholinoceptor blockade, with either atropine or mecamylamine abolishes the vasodilator effect of substance P. Chemical sympathectomy of the hypothalamus with 6‐hydroxydopamine, or adrenoceptor blockade with either propranolol or phenoxybenzamine abolishes the effect of substance P on HBF. Destruction of the intracerebral noradrenergic pathway (INP), or blockade of its vasodilator action, with barbiturate or bicarbonate, likewise prevent the vasodilator action of substance P. These results suggest that substance P may cause an increase in HBF via the release of endogenous acetylcholine, which in turn stimulates the INP. 1980 British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0019163609&partnerID=8YFLogxK
U2 - 10.1111/j.1476-5381.1980.tb10982.x
DO - 10.1111/j.1476-5381.1980.tb10982.x
M3 - Article
C2 - 6162500
AN - SCOPUS:0019163609
SN - 0007-1188
VL - 71
SP - 623
EP - 629
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 2
ER -