TY - JOUR
T1 - Substance P immunoreactivity in Alzheimer disease
T2 - A study in cases presenting symmetric or asymmetric cortical atrophy
AU - Bouras, C.
AU - Vallet, P. G.
AU - Hof, P. R.
AU - Charnay, Y.
AU - Golaz, J.
AU - Constantinidis, J.
PY - 1990
Y1 - 1990
N2 - Substance P-like immunoreactivity was visualized by immunohistochemical methods in 20 postmortem brains: 6 senile, 4 presenile Alzheimer dementia (AD), 3 AD with interhemispheric asymmetric cortical atrophy, and 7 control cases. For all pathological cases, the SP-like immunoreactivity was significantly reduced in the neocortical areas and in the hippocampus. This contrasted with an enhanced SP-like immunoreactivity in the pallidum and the substantia nigra in AD brains and a more pronounced SP-like immunoreactivity in the more atrophic side in the asymmetrically atrophied brains.
AB - Substance P-like immunoreactivity was visualized by immunohistochemical methods in 20 postmortem brains: 6 senile, 4 presenile Alzheimer dementia (AD), 3 AD with interhemispheric asymmetric cortical atrophy, and 7 control cases. For all pathological cases, the SP-like immunoreactivity was significantly reduced in the neocortical areas and in the hippocampus. This contrasted with an enhanced SP-like immunoreactivity in the pallidum and the substantia nigra in AD brains and a more pronounced SP-like immunoreactivity in the more atrophic side in the asymmetrically atrophied brains.
UR - http://www.scopus.com/inward/record.url?scp=0025183053&partnerID=8YFLogxK
U2 - 10.1097/00002093-199040100-00003
DO - 10.1097/00002093-199040100-00003
M3 - Article
C2 - 1690554
AN - SCOPUS:0025183053
SN - 0893-0341
VL - 4
SP - 24
EP - 34
JO - Alzheimer Disease and Associated Disorders
JF - Alzheimer Disease and Associated Disorders
IS - 1
ER -