Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease

R. Theodore Smith; Timothy W. Olsen; Victor Chong; Judy Kim; Martin Hammer; Gareth Lema; Avnish Deobhakta; Anna Tan; Yuehong Tong; Katy Tai; Yang Fei; Emanuel Mordechaev; Gerardo Ledesma-Gil; Oscar Otero-Marquez; Richard B. Rosen; Alauddin Bhuiyan; Sobha Sivaprasad; Philip J. Rosenfeld

doi:10.1016/j.apjo.2024.100036

Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease

R. Theodore Smith, Timothy W. Olsen, Victor Chong, Judy Kim, Martin Hammer, Gareth Lema, Avnish Deobhakta, Anna Tan, Yuehong Tong, Katy Tai, Yang Fei, Emanuel Mordechaev, Gerardo Ledesma-Gil, Oscar Otero-Marquez, Richard B. Rosen, Alauddin Bhuiyan, Sobha Sivaprasad, Philip J. Rosenfeld

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of AMD on retinal imaging and certain co-existent vascular diseases that are high risk for compromised cardiac output or internal carotid artery stenosis. Future screening initiatives for these high -risk vascular diseases (HRVDs) with fast, inexpensive retinal imaging could make a significant contribution to public health and save lives. Likewise, screening patients with known HRVDs for unrecognized AMD of the SDD form could enable needed treatment and save vision.

Original language	English
Article number	100036
Journal	Asia-Pacific Journal of Ophthalmology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/j.apjo.2024.100036
State	Published - Jan 2024
Externally published	Yes

Keywords

Age related macular degeneration (AMD)
Cardiovascular disease (CVD)
High-risk vascular diseases (HRVDs)
Subretinal drusenoid deposits (SDD)

Access to Document

10.1016/j.apjo.2024.100036

Cite this

Smith, R. T., Olsen, T. W., Chong, V., Kim, J., Hammer, M., Lema, G., Deobhakta, A., Tan, A., Tong, Y., Tai, K., Fei, Y., Mordechaev, E., Ledesma-Gil, G., Otero-Marquez, O., Rosen, R. B., Bhuiyan, A., Sivaprasad, S., & Rosenfeld, P. J. (2024). Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease. Asia-Pacific Journal of Ophthalmology, 13(1), Article 100036. https://doi.org/10.1016/j.apjo.2024.100036

@article{64e773058be248ec9b95bbdb96f137c1,

title = "Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease",

abstract = "Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of AMD on retinal imaging and certain co-existent vascular diseases that are high risk for compromised cardiac output or internal carotid artery stenosis. Future screening initiatives for these high -risk vascular diseases (HRVDs) with fast, inexpensive retinal imaging could make a significant contribution to public health and save lives. Likewise, screening patients with known HRVDs for unrecognized AMD of the SDD form could enable needed treatment and save vision.",

keywords = "Age related macular degeneration (AMD), Cardiovascular disease (CVD), High-risk vascular diseases (HRVDs), Subretinal drusenoid deposits (SDD)",

author = "Smith, {R. Theodore} and Olsen, {Timothy W.} and Victor Chong and Judy Kim and Martin Hammer and Gareth Lema and Avnish Deobhakta and Anna Tan and Yuehong Tong and Katy Tai and Yang Fei and Emanuel Mordechaev and Gerardo Ledesma-Gil and Oscar Otero-Marquez and Rosen, {Richard B.} and Alauddin Bhuiyan and Sobha Sivaprasad and Rosenfeld, {Philip J.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = jan,

doi = "10.1016/j.apjo.2024.100036",

language = "English",

volume = "13",

journal = "Asia-Pacific Journal of Ophthalmology",

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Smith, RT, Olsen, TW, Chong, V, Kim, J, Hammer, M, Lema, G , Deobhakta, A, Tan, A, Tong, Y, Tai, K, Fei, Y, Mordechaev, E, Ledesma-Gil, G, Otero-Marquez, O, Rosen, RB, Bhuiyan, A, Sivaprasad, S & Rosenfeld, PJ 2024, 'Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease', Asia-Pacific Journal of Ophthalmology, vol. 13, no. 1, 100036. https://doi.org/10.1016/j.apjo.2024.100036

TY - JOUR

T1 - Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease

AU - Smith, R. Theodore

AU - Olsen, Timothy W.

AU - Chong, Victor

AU - Kim, Judy

AU - Hammer, Martin

AU - Lema, Gareth

AU - Deobhakta, Avnish

AU - Tan, Anna

AU - Tong, Yuehong

AU - Tai, Katy

AU - Fei, Yang

AU - Mordechaev, Emanuel

AU - Ledesma-Gil, Gerardo

AU - Otero-Marquez, Oscar

AU - Rosen, Richard B.

AU - Bhuiyan, Alauddin

AU - Sivaprasad, Sobha

AU - Rosenfeld, Philip J.

PY - 2024/1

Y1 - 2024/1

N2 - Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of AMD on retinal imaging and certain co-existent vascular diseases that are high risk for compromised cardiac output or internal carotid artery stenosis. Future screening initiatives for these high -risk vascular diseases (HRVDs) with fast, inexpensive retinal imaging could make a significant contribution to public health and save lives. Likewise, screening patients with known HRVDs for unrecognized AMD of the SDD form could enable needed treatment and save vision.

AB - Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of AMD on retinal imaging and certain co-existent vascular diseases that are high risk for compromised cardiac output or internal carotid artery stenosis. Future screening initiatives for these high -risk vascular diseases (HRVDs) with fast, inexpensive retinal imaging could make a significant contribution to public health and save lives. Likewise, screening patients with known HRVDs for unrecognized AMD of the SDD form could enable needed treatment and save vision.

KW - Age related macular degeneration (AMD)

KW - Cardiovascular disease (CVD)

KW - High-risk vascular diseases (HRVDs)

KW - Subretinal drusenoid deposits (SDD)

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U2 - 10.1016/j.apjo.2024.100036

DO - 10.1016/j.apjo.2024.100036

M3 - Review article

AN - SCOPUS:85184068779

SN - 2162-0989

VL - 13

JO - Asia-Pacific Journal of Ophthalmology

JF - Asia-Pacific Journal of Ophthalmology

IS - 1

M1 - 100036

ER -

Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease

Abstract

Keywords

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