TY - JOUR
T1 - Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal
AU - Apostolova, Liana G.
AU - Mosconi, Lisa
AU - Thompson, Paul M.
AU - Green, Amity E.
AU - Hwang, Kristy S.
AU - Ramirez, Anthony
AU - Mistur, Rachel
AU - Tsui, Wai H.
AU - de Leon, Mony J.
N1 - Funding Information:
This work was generously supported by NIA K23 AG026803 (jointly sponsored by NIA, AFAR, The John A. Hartford Foundation, the Atlantic Philanthropies, the Starr Foundation and an anonymous donor; to LGA), NIA P50 AG16570 (to LGA and PMT); NIBIB EB01651, NLM LM05639, NCRR RR019771, NIH/NIMH R01 MH071940, NIH/NCRR P41 RR013642 and NIH U54 RR021813 (to PMT); the Alzheimer's Association (to LM); and NIH-NIA AG13616, AG12101, AG08051, and AG022374 (to MdL).
PY - 2010/7
Y1 - 2010/7
N2 - Atrophic changes of the hippocampus are typically regarded as an early sign of Alzheimer's dementia (AD). Using the radial distance atrophy mapping approach, we compared the longitudinal MRI data of 10 cognitively normal elderly subjects who remained normal at 3-year and 6-year follow-up (NL-NL) and 7 cognitively normal elderly subjects who were diagnosed with mild cognitive impairment (MCI) 2.8 (range 2.0-3.9) and with AD 6.8 years (range 6.1-8.2) after baseline (NL-MCIAD). 3D statistical maps revealed greater hippocampal atrophy in the NL-MCIAD relative to the NL-NL group at baseline (left p=0.05; right p=0.06) corresponding to 10-15% CA1, and 10-25% subicular atrophy, and bilateral differences at 3-year follow-up (left p=0.001, right p<0.02) corresponding to 10-30% subicular, 10-20% CA1, and 10-20% newly developed CA2-3 atrophy. This preliminary study suggests that excess CA1 and subicular atrophy is present in cognitively normal individuals predestined to decline to amnestic MCI, while progressive involvement of the CA1 and subiculum, and atrophy spreading to the CA2-3 subfield in amnestic MCI, suggests future diagnosis of AD.
AB - Atrophic changes of the hippocampus are typically regarded as an early sign of Alzheimer's dementia (AD). Using the radial distance atrophy mapping approach, we compared the longitudinal MRI data of 10 cognitively normal elderly subjects who remained normal at 3-year and 6-year follow-up (NL-NL) and 7 cognitively normal elderly subjects who were diagnosed with mild cognitive impairment (MCI) 2.8 (range 2.0-3.9) and with AD 6.8 years (range 6.1-8.2) after baseline (NL-MCIAD). 3D statistical maps revealed greater hippocampal atrophy in the NL-MCIAD relative to the NL-NL group at baseline (left p=0.05; right p=0.06) corresponding to 10-15% CA1, and 10-25% subicular atrophy, and bilateral differences at 3-year follow-up (left p=0.001, right p<0.02) corresponding to 10-30% subicular, 10-20% CA1, and 10-20% newly developed CA2-3 atrophy. This preliminary study suggests that excess CA1 and subicular atrophy is present in cognitively normal individuals predestined to decline to amnestic MCI, while progressive involvement of the CA1 and subiculum, and atrophy spreading to the CA2-3 subfield in amnestic MCI, suggests future diagnosis of AD.
KW - Alzheimer's disease (AD)
KW - Hippocampus
KW - Magnetic resonance imaging (MRI)
KW - Memory
KW - Mild cognitive impairment (MCI)
KW - Predicting cognitive decline
UR - http://www.scopus.com/inward/record.url?scp=77952878939&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2008.08.008
DO - 10.1016/j.neurobiolaging.2008.08.008
M3 - Article
C2 - 18814937
AN - SCOPUS:77952878939
SN - 0197-4580
VL - 31
SP - 1077
EP - 1088
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 7
ER -