Submucosal nerve hypertrophy in congenital laryngomalacia

Patrick D. Munson; Ali G. Saad; Siraj M. El-Jamal; Yuemeng Dai; Charles M. Bower; Gresham T. Richter

doi:10.1002/lary.21360

Submucosal nerve hypertrophy in congenital laryngomalacia

Patrick D. Munson, Ali G. Saad, Siraj M. El-Jamal, Yuemeng Dai, Charles M. Bower, Gresham T. Richter

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Objectives/Hypothesis: To determine the neuropathologic findings in tissue obtained from children with laryngomalacia at a tertiary-care pediatric hospital. Study Design: Retrospective review of consecutive cohort compared with a control group. Methods: We reviewed supra-arytenoid pathology specimens from 43 children with severe laryngomalacia and 13 age-matched pediatric autopsy controls. Histopathologic comparison was made of nerve hypertrophy (including nerve perimeter and surface area) among experimental and control pathologic specimens. Results: There exists a statistically significant increase in nerve perimeter (P =.001) and nerve surface area (P =.02) in supra-arytenoid specimens in patients with severe laryngomalacia compared with age-matched autopsy supra-arytenoid tissue. Conclusions: The pathologic finding of nerve hypertrophy in children with laryngomalacia provides new evidence to support neurologic dysfunction as the etiologic theory of laryngomalacia.

Original language	English
Pages (from-to)	627-629
Number of pages	3
Journal	Laryngoscope
Volume	121
Issue number	3
DOIs	https://doi.org/10.1002/lary.21360
State	Published - Mar 2011
Externally published	Yes

Keywords

Laryngomalacia
histopathology
nerve hypertrophy

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10.1002/lary.21360

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title = "Submucosal nerve hypertrophy in congenital laryngomalacia",

abstract = "Objectives/Hypothesis: To determine the neuropathologic findings in tissue obtained from children with laryngomalacia at a tertiary-care pediatric hospital. Study Design: Retrospective review of consecutive cohort compared with a control group. Methods: We reviewed supra-arytenoid pathology specimens from 43 children with severe laryngomalacia and 13 age-matched pediatric autopsy controls. Histopathologic comparison was made of nerve hypertrophy (including nerve perimeter and surface area) among experimental and control pathologic specimens. Results: There exists a statistically significant increase in nerve perimeter (P =.001) and nerve surface area (P =.02) in supra-arytenoid specimens in patients with severe laryngomalacia compared with age-matched autopsy supra-arytenoid tissue. Conclusions: The pathologic finding of nerve hypertrophy in children with laryngomalacia provides new evidence to support neurologic dysfunction as the etiologic theory of laryngomalacia.",

keywords = "Laryngomalacia, histopathology, nerve hypertrophy",

author = "Munson, {Patrick D.} and Saad, {Ali G.} and El-Jamal, {Siraj M.} and Yuemeng Dai and Bower, {Charles M.} and Richter, {Gresham T.}",

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doi = "10.1002/lary.21360",

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journal = "Laryngoscope",

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T1 - Submucosal nerve hypertrophy in congenital laryngomalacia

AU - Munson, Patrick D.

AU - Saad, Ali G.

AU - El-Jamal, Siraj M.

AU - Dai, Yuemeng

AU - Bower, Charles M.

AU - Richter, Gresham T.

PY - 2011/3

Y1 - 2011/3

N2 - Objectives/Hypothesis: To determine the neuropathologic findings in tissue obtained from children with laryngomalacia at a tertiary-care pediatric hospital. Study Design: Retrospective review of consecutive cohort compared with a control group. Methods: We reviewed supra-arytenoid pathology specimens from 43 children with severe laryngomalacia and 13 age-matched pediatric autopsy controls. Histopathologic comparison was made of nerve hypertrophy (including nerve perimeter and surface area) among experimental and control pathologic specimens. Results: There exists a statistically significant increase in nerve perimeter (P =.001) and nerve surface area (P =.02) in supra-arytenoid specimens in patients with severe laryngomalacia compared with age-matched autopsy supra-arytenoid tissue. Conclusions: The pathologic finding of nerve hypertrophy in children with laryngomalacia provides new evidence to support neurologic dysfunction as the etiologic theory of laryngomalacia.

AB - Objectives/Hypothesis: To determine the neuropathologic findings in tissue obtained from children with laryngomalacia at a tertiary-care pediatric hospital. Study Design: Retrospective review of consecutive cohort compared with a control group. Methods: We reviewed supra-arytenoid pathology specimens from 43 children with severe laryngomalacia and 13 age-matched pediatric autopsy controls. Histopathologic comparison was made of nerve hypertrophy (including nerve perimeter and surface area) among experimental and control pathologic specimens. Results: There exists a statistically significant increase in nerve perimeter (P =.001) and nerve surface area (P =.02) in supra-arytenoid specimens in patients with severe laryngomalacia compared with age-matched autopsy supra-arytenoid tissue. Conclusions: The pathologic finding of nerve hypertrophy in children with laryngomalacia provides new evidence to support neurologic dysfunction as the etiologic theory of laryngomalacia.

KW - Laryngomalacia

KW - histopathology

KW - nerve hypertrophy

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JO - Laryngoscope

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Submucosal nerve hypertrophy in congenital laryngomalacia

Abstract

Keywords

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