Subcellular distribution of diacylglycerol lipase in rat and mouse brain

A. Rousseau, G. Dubois, S. Gatt

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Rat Brain has a lipase which hydrolyzes diacylglycerol at an optimal pH of 4.8 (1). The subcellular distribution of this acid diacylglycerol lipase was studied in brain tissue of rats and mice; in the latter case neurological mutants and their normal controls were used. Several other acidic hydrolases were employed as lysosomal markers. In mouse brain, the specific activity which is about 50-100 times lower than in rat brain, was greatest in the lysosomal fraction. In contrast, no enrichment of DG-lipase was observed in any subcellular fraction of the active enzyme of rat brain. Activities were about equally distributed in the microsomal, myelin-synaptosomal and lysosomal fractions.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalNeurochemical Research
Issue number4
StatePublished - Apr 1983
Externally publishedYes


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