TY - JOUR
T1 - STUDY ON THE INHIBITORY EFFECT OF TOTAL ALKALIODS OF SOPHORA ALOPECUROIDES ON OSTEOSARCOMA CELL GROWTH
AU - Lu, Xiang
AU - Lin, Bin
AU - Tang, Jia Guang
AU - Cao, Zheng
AU - Hu, Yuan
N1 - Publisher Copyright:
© 2014, African Traditional, Herbal Medicine Supporters Initiative. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Background: Ku Dou Zi is the dried whole plant, roots and seeds of Sophora alopecuroides L. in the genus Sophora of family Leguminosae. The entire plant is bitter in taste, cold in nature, and has the heat clearing, detoxifying, pathogenic wind dispelling dampness, analgesic, and insecticidal effects. Modern pharmacological studies have proved that TASA has pharmacological activities of anti-cancer. The objective of this paper was to investigate the inhibitory effect of total alkaloids of Sophora alopecuroides (TASA), on osteosarcoma cell growth and its mechanism. Materials and Methods: MTT assay and flow cytometry were used to study the inhibitory effect of TASA on human osteosarcoma cell line OS732. Results: The results showed that the inhibition rates of different concentrations of TASA (1.5, 3, and 4.5g/kg), against human osteosarcoma cell line OS732, were: 18.4%, 27.4% and 52.8%, respectively. Conclusion: TASA has an inhibitory effect on osteosarcoma cell growth.
AB - Background: Ku Dou Zi is the dried whole plant, roots and seeds of Sophora alopecuroides L. in the genus Sophora of family Leguminosae. The entire plant is bitter in taste, cold in nature, and has the heat clearing, detoxifying, pathogenic wind dispelling dampness, analgesic, and insecticidal effects. Modern pharmacological studies have proved that TASA has pharmacological activities of anti-cancer. The objective of this paper was to investigate the inhibitory effect of total alkaloids of Sophora alopecuroides (TASA), on osteosarcoma cell growth and its mechanism. Materials and Methods: MTT assay and flow cytometry were used to study the inhibitory effect of TASA on human osteosarcoma cell line OS732. Results: The results showed that the inhibition rates of different concentrations of TASA (1.5, 3, and 4.5g/kg), against human osteosarcoma cell line OS732, were: 18.4%, 27.4% and 52.8%, respectively. Conclusion: TASA has an inhibitory effect on osteosarcoma cell growth.
KW - flow cytometry
KW - human osteosarcoma cell line OS732
KW - total alkaloids of Sophora alopecuroides
UR - https://www.scopus.com/pages/publications/84908895587
U2 - 10.4314/ajtcam.v11i1.27
DO - 10.4314/ajtcam.v11i1.27
M3 - Article
C2 - 24653573
AN - SCOPUS:84908895587
SN - 0189-6016
VL - 11
SP - 172
EP - 175
JO - African Journal of Traditional, Complementary and Alternative Medicines
JF - African Journal of Traditional, Complementary and Alternative Medicines
IS - 1
ER -