Study on disintegration site of tinidazol tablets for colonic drug delivery by gamma scintigraphy

Mei ling Qi; Peng Wang; De zheng Wu

Study on disintegration site of tinidazol tablets for colonic drug delivery by gamma scintigraphy

Mei ling Qi, Peng Wang, De zheng Wu

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To determine the disintegration site of colonic drug delivery tablets in the gastrointestinal tract. METHOD: The tablets lablled with ¹⁵³Sm, using tinidazole as the model drug, were administered by two healthy male volunteers and then traced by gamma scintigraphy to find the site where the tablets disintegrated and released the drug. RESULTS: The disintegration site of the tablets was in the ascending colon, and the disintegration time was between 7 h and 8 h. CONCLUTION: The tablets delivered the drug to the colon.

Original language	English
Pages (from-to)	114-116
Number of pages	3
Journal	Chinese Pharmaceutical Journal
Volume	38
Issue number	2
State	Published - 1 Feb 2003
Externally published	Yes

Keywords

Colonic drug delivery tablets
Gamma scintigraphy
In vivo drug release
Tinidazole

Cite this

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title = "Study on disintegration site of tinidazol tablets for colonic drug delivery by gamma scintigraphy",

abstract = "OBJECTIVE: To determine the disintegration site of colonic drug delivery tablets in the gastrointestinal tract. METHOD: The tablets lablled with 153Sm, using tinidazole as the model drug, were administered by two healthy male volunteers and then traced by gamma scintigraphy to find the site where the tablets disintegrated and released the drug. RESULTS: The disintegration site of the tablets was in the ascending colon, and the disintegration time was between 7 h and 8 h. CONCLUTION: The tablets delivered the drug to the colon.",

keywords = "Colonic drug delivery tablets, Gamma scintigraphy, In vivo drug release, Tinidazole",

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AU - Wang, Peng

AU - Wu, De zheng

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N2 - OBJECTIVE: To determine the disintegration site of colonic drug delivery tablets in the gastrointestinal tract. METHOD: The tablets lablled with 153Sm, using tinidazole as the model drug, were administered by two healthy male volunteers and then traced by gamma scintigraphy to find the site where the tablets disintegrated and released the drug. RESULTS: The disintegration site of the tablets was in the ascending colon, and the disintegration time was between 7 h and 8 h. CONCLUTION: The tablets delivered the drug to the colon.

AB - OBJECTIVE: To determine the disintegration site of colonic drug delivery tablets in the gastrointestinal tract. METHOD: The tablets lablled with 153Sm, using tinidazole as the model drug, were administered by two healthy male volunteers and then traced by gamma scintigraphy to find the site where the tablets disintegrated and released the drug. RESULTS: The disintegration site of the tablets was in the ascending colon, and the disintegration time was between 7 h and 8 h. CONCLUTION: The tablets delivered the drug to the colon.

KW - Colonic drug delivery tablets

KW - Gamma scintigraphy

KW - In vivo drug release

KW - Tinidazole

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JO - Chinese Pharmaceutical Journal

JF - Chinese Pharmaceutical Journal

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Study on disintegration site of tinidazol tablets for colonic drug delivery by gamma scintigraphy

Abstract

Keywords

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