TY - JOUR
T1 - Study of the temporal effects on conduction and refractoriness of the His-Purkinje system in man
AU - Reddy, C. Pratap
AU - Damato, Anthony N.
AU - Akhtar, Masood
AU - Dhatt, Malkiat S.
AU - Gomes, Joseph A.
AU - Foster, James R.
N1 - Funding Information:
From the Cardiopulmonary Laboratory, Hospital, Staten Island, N. Y. This work wss supported in part by the Bureau of Medical Services, National Heart, Lung and Blood Institute, Project HL 12436-06. Received for publication Aug. 29, 1977. Accepted for publication Oct. 25, 1977. Reprint requests: Anth0ny.N. Dam&o, M.D., United States Public Health Service Hospital, Staten Island, N. Y. 10304. *Present address: Department of Medicine, University of Kentucky, College of Medicine, Lexington, Ky.
PY - 1978/9
Y1 - 1978/9
N2 - Temporal effects on refractoriness within the His-Purkinje system (HPS) were studied in 14 patients in whom effective refractory period (ERP) of HPS could be determined, using His bundle electrograms, incremental atrial pacing, and atrial extrastimulus method. His-Purkinje conduction times (H-V interval) and relative (R), effective (E), and functional (F) refractory periods (RP) of HPS were measured during the control period and repeat measurements were made after a 30 minute interval, H-V intervals were unchanged from control in all patients. Although changes of the magnitude of 5 to 25 msec. in either direction from control values commonly occurred, on the average, no statistically significant changes were seen in RRP, ERP, or FRP of HPS. The results of the present study confirm the stability of refractoriness of HPS over a 30 minute period and provide baseline data for future investigations of cardiovascular drugs which act primarily on the distal part of the A-V conduction system.
AB - Temporal effects on refractoriness within the His-Purkinje system (HPS) were studied in 14 patients in whom effective refractory period (ERP) of HPS could be determined, using His bundle electrograms, incremental atrial pacing, and atrial extrastimulus method. His-Purkinje conduction times (H-V interval) and relative (R), effective (E), and functional (F) refractory periods (RP) of HPS were measured during the control period and repeat measurements were made after a 30 minute interval, H-V intervals were unchanged from control in all patients. Although changes of the magnitude of 5 to 25 msec. in either direction from control values commonly occurred, on the average, no statistically significant changes were seen in RRP, ERP, or FRP of HPS. The results of the present study confirm the stability of refractoriness of HPS over a 30 minute period and provide baseline data for future investigations of cardiovascular drugs which act primarily on the distal part of the A-V conduction system.
UR - https://www.scopus.com/pages/publications/0018078514
U2 - 10.1016/0002-8703(78)90042-X
DO - 10.1016/0002-8703(78)90042-X
M3 - Article
C2 - 685805
AN - SCOPUS:0018078514
SN - 0002-8703
VL - 96
SP - 316
EP - 325
JO - American Heart Journal
JF - American Heart Journal
IS - 3
ER -