Studies on xenogenic antisera to tumor-associated antigen of ovarian carcinoma

Michael A. Gerber; Isidoro Faiferman; Carmel J. Cohen; David Koffler

doi:10.1016/0090-1229(77)90107-6

Studies on xenogenic antisera to tumor-associated antigen of ovarian carcinoma

Michael A. Gerber
, Isidoro Faiferman
, Carmel J. Cohen
, David Koffler

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Xenogenic antisera prepared to KCl, perchloric acid, and deoxycholate extracts of serous cystadenocarcinoma of the ovary contain antibodies with specificity for ovarian carcinoma cells. In order to demonstrate selective reactivity with ovarian carcinoma sequential absorption with several normal tissues was required. Characterization of the tumor-associated antigen(s) suggests that it is a glycoprotein which appears in the exclusion volume of a Sephadex G-200 column. It is resistant to formalin fixation and processing and distinct from colonic carcinoembryonic antigen. The antigen was demonstrable in varying concentrations in the cytoplasm of nine ovarian carcinomas, and was absent from normal ovary and five unrelated types of carcinoma studied.

Original language	English
Pages (from-to)	171-180
Number of pages	10
Journal	Clinical Immunology and Immunopathology
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(77)90107-6
State	Published - Sep 1977
Externally published	Yes

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title = "Studies on xenogenic antisera to tumor-associated antigen of ovarian carcinoma",

abstract = "Xenogenic antisera prepared to KCl, perchloric acid, and deoxycholate extracts of serous cystadenocarcinoma of the ovary contain antibodies with specificity for ovarian carcinoma cells. In order to demonstrate selective reactivity with ovarian carcinoma sequential absorption with several normal tissues was required. Characterization of the tumor-associated antigen(s) suggests that it is a glycoprotein which appears in the exclusion volume of a Sephadex G-200 column. It is resistant to formalin fixation and processing and distinct from colonic carcinoembryonic antigen. The antigen was demonstrable in varying concentrations in the cytoplasm of nine ovarian carcinomas, and was absent from normal ovary and five unrelated types of carcinoma studied.",

author = "Gerber, \{Michael A.\} and Isidoro Faiferman and Cohen, \{Carmel J.\} and David Koffler",

note = "Funding Information: 1 This work was supported by the Mount Sinai Gynecological Cancer Research Fund and U. S. Public Health Service Grant AMl3721-03. 2 Dr. Gerber is recipient of a Research Career Development Award (1 KO 4 Al 00035-01) from the U.S. Public Health Service.",

year = "1977",

month = sep,

doi = "10.1016/0090-1229(77)90107-6",

language = "English",

volume = "8",

pages = "171--180",

journal = "Clinical Immunology and Immunopathology",

issn = "0090-1229",

publisher = "Academic Press Inc.",

number = "2",

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TY - JOUR

T1 - Studies on xenogenic antisera to tumor-associated antigen of ovarian carcinoma

AU - Gerber, Michael A.

AU - Faiferman, Isidoro

AU - Cohen, Carmel J.

AU - Koffler, David

N1 - Funding Information: 1 This work was supported by the Mount Sinai Gynecological Cancer Research Fund and U. S. Public Health Service Grant AMl3721-03. 2 Dr. Gerber is recipient of a Research Career Development Award (1 KO 4 Al 00035-01) from the U.S. Public Health Service.

PY - 1977/9

Y1 - 1977/9

N2 - Xenogenic antisera prepared to KCl, perchloric acid, and deoxycholate extracts of serous cystadenocarcinoma of the ovary contain antibodies with specificity for ovarian carcinoma cells. In order to demonstrate selective reactivity with ovarian carcinoma sequential absorption with several normal tissues was required. Characterization of the tumor-associated antigen(s) suggests that it is a glycoprotein which appears in the exclusion volume of a Sephadex G-200 column. It is resistant to formalin fixation and processing and distinct from colonic carcinoembryonic antigen. The antigen was demonstrable in varying concentrations in the cytoplasm of nine ovarian carcinomas, and was absent from normal ovary and five unrelated types of carcinoma studied.

AB - Xenogenic antisera prepared to KCl, perchloric acid, and deoxycholate extracts of serous cystadenocarcinoma of the ovary contain antibodies with specificity for ovarian carcinoma cells. In order to demonstrate selective reactivity with ovarian carcinoma sequential absorption with several normal tissues was required. Characterization of the tumor-associated antigen(s) suggests that it is a glycoprotein which appears in the exclusion volume of a Sephadex G-200 column. It is resistant to formalin fixation and processing and distinct from colonic carcinoembryonic antigen. The antigen was demonstrable in varying concentrations in the cytoplasm of nine ovarian carcinomas, and was absent from normal ovary and five unrelated types of carcinoma studied.

UR - https://www.scopus.com/pages/publications/0017714474

U2 - 10.1016/0090-1229(77)90107-6

DO - 10.1016/0090-1229(77)90107-6

M3 - Article

C2 - 198173

AN - SCOPUS:0017714474

SN - 0090-1229

VL - 8

SP - 171

EP - 180

JO - Clinical Immunology and Immunopathology

JF - Clinical Immunology and Immunopathology

IS - 2

ER -

Studies on xenogenic antisera to tumor-associated antigen of ovarian carcinoma

Abstract

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