Abstract
The Eichwald-Silmser phenomenon (rejection of male skin graft by isogenic females of certain strains) and the sexual dimorphism in the anti-A antibody production are demonstrated to be unrelated. These studies show no A-like antigenic activity on tissues of C57BL/10 males. While anti-B production is induced in both males and females with one injection, males require a large dose in primary immunization or secondary immunization to produce anti-A antibody and the titers are always lower than in the females. It is proposed that the difference between males and females in the spontaneous production of anti-A-like agglutinins is attributable to genetic control of this immunological response.
| Original language | English |
|---|---|
| Pages (from-to) | 111-115 |
| Number of pages | 5 |
| Journal | Transplantation |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1973 |