Abstract
Four patients with recurrent cysteine stones and 5 with rheumatoid arthritis (RA) were studied. After a single dose of D-penicillamine to cystinuric patients, cystine excretion decreased considerably. Cysteine-penicillamine mixed disulfide (CSSP) and penicillamine disulfide (PSSP) metabolites appeared within 1-2 h (CSSP/PSSP≃ 4.8-8.6). In RA, cystine excretion remained negligible (CSSP/PSSP≃ 1.4-2.9). With daily D-penicillamine in RA (CSSP/PSSP ratios were usually > 7 in those with favorable clinical response. CSSP/PSSP ratios may help to predict prognosis and adjust penicillamine dosage. Coadministration of probenecid is contraindicated in hyperuricemic cystinuric patients because of increased cystine and decreased CSSP and PSSP excretion.
| Original language | English |
|---|---|
| Pages (from-to) | 467-470 |
| Number of pages | 4 |
| Journal | Journal of Rheumatology |
| Volume | 11 |
| Issue number | 4 |
| State | Published - 1984 |
| Externally published | Yes |