TY - JOUR
T1 - Studies on the Epstein Barr virus genome and the EBV determined nuclear antigen in human malignant disease
AU - Klein, G.
PY - 1974
Y1 - 1974
N2 - The results summarized in this paper purport to show that there is a profound difference in the validity and significance of Epstein Barr virus association with Burkitt's lymphoma and nasopharyngeal carcinoma, on the one hand and chronic lymphocytic leukemia, Hodgkin's disease and lymphocytic lymphoma, as judged by nucleic acid hybridization and EBNA (EBV determined nuclear antigen) tests on the other. This is followed by some studies concerned with host cell control of viral functions, including evidence that biologically different viral variants exist. Finally, an attempt is made to formulate the main alternatives that can account for the association between the virus and human malignancies.
AB - The results summarized in this paper purport to show that there is a profound difference in the validity and significance of Epstein Barr virus association with Burkitt's lymphoma and nasopharyngeal carcinoma, on the one hand and chronic lymphocytic leukemia, Hodgkin's disease and lymphocytic lymphoma, as judged by nucleic acid hybridization and EBNA (EBV determined nuclear antigen) tests on the other. This is followed by some studies concerned with host cell control of viral functions, including evidence that biologically different viral variants exist. Finally, an attempt is made to formulate the main alternatives that can account for the association between the virus and human malignancies.
UR - http://www.scopus.com/inward/record.url?scp=0016340715&partnerID=8YFLogxK
U2 - 10.1101/sqb.1974.039.01.090
DO - 10.1101/sqb.1974.039.01.090
M3 - Article
C2 - 169032
AN - SCOPUS:0016340715
SN - 0091-7451
VL - 39
SP - 783
EP - 790
JO - Cold Spring Harbor Symposia on Quantitative Biology
JF - Cold Spring Harbor Symposia on Quantitative Biology
IS - 2
ER -