Studies on nicardipine hydrochloride timed-release tablets

Meiling Qi, Peng Wang, Junmin Zheng, Ruhua Zhang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


AIM: To investigate timed-release as to its timed-release effects both in vitro and in vivo. METHODS: Nicardipine hydrochloride was used as the model drug. The timed-release tablets were prepared by means of dry compression coating techniques. Two time parameters t0.1 and t0.8 were first presented and used to evaluate the influences of factors, such as the amount of PEG6000, the grade of ethylcellulose viscosity, tablet outercoat thickness and tablet hardness, on nicardipine release. The drug release mechanism was assured by an erosion experiment. Human pharmacokinetics was studies in five male volunteers using HPLC. RESULTS: In vitro the timed release tablets began to release the drug at about (6.5±0.3) h and ended at about (8.0±0.3) h; for the time-release tablets and the normal tablets in vivo, the tmax and lag time were (8.3±0.4) h, (1.3±0.4) h and (6.4±0.3) h and (0.4±0.04) h, respectively. The comparative bioavailability of the time-released tablets over the normal tablets was 93.6% ± 8.8%. CONCLUSION: The timed-release effects of nicardipine timed-release tablets were significant both in vitro and in vivo.

Original languageEnglish
Pages (from-to)710-715
Number of pages6
JournalYaoxue Xuebao
Issue number9
StatePublished - Sep 1999
Externally publishedYes


  • Drug release in vitro
  • Dry compression coating
  • Human pharmacokinetics
  • Nicardipine hydrochloride
  • Timed-release tablets


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