Studies of adipose tissue metabolism in human immunodeficiency virus - Associated lipodystrophy

Donald P. Kotler; Gabriel Ionescu; Julia A. Johnson; Yori Inada; Qing He; Ellen S. Engelson; Jeanine B. Albu

doi:10.1086/375891

Studies of adipose tissue metabolism in human immunodeficiency virus - Associated lipodystrophy

Donald P. Kotler, Gabriel Ionescu, Julia A. Johnson, Yori Inada, Qing He, Ellen S. Engelson, Jeanine B. Albu

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We studied aspects of metabolism in subcutaneous adipose tissue (SAT) in 40 human immunodeficiency virus (HIV)-infected subjects with and without lipodystrophy and in healthy control subjects. HIV-infected subjects without lipodystrophy had less SAT and visceral adipose tissue (VAT). Glycerol release was higher in both HIV-infected groups, especially those without fat redistribution. Tumor necrosis factor (TNF) release from SAT and serum soluble TNF receptor 2 concentrations were significantly higher in HIV-infected individuals with lipodystrophy. The absolute production of acylation-stimulating protein (ASP) and the percentage conversion of the complement protein to ASP were significantly lower in HIV-infected subjects with lipodystrophy. Further studies are needed to dissect the factors that mediate lipoatrophy in HIV infection.

Original language	English
Pages (from-to)	S47-S51
Journal	Clinical Infectious Diseases
Volume	37
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1086/375891
State	Published - 1 Sep 2003
Externally published	Yes

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abstract = "We studied aspects of metabolism in subcutaneous adipose tissue (SAT) in 40 human immunodeficiency virus (HIV)-infected subjects with and without lipodystrophy and in healthy control subjects. HIV-infected subjects without lipodystrophy had less SAT and visceral adipose tissue (VAT). Glycerol release was higher in both HIV-infected groups, especially those without fat redistribution. Tumor necrosis factor (TNF) release from SAT and serum soluble TNF receptor 2 concentrations were significantly higher in HIV-infected individuals with lipodystrophy. The absolute production of acylation-stimulating protein (ASP) and the percentage conversion of the complement protein to ASP were significantly lower in HIV-infected subjects with lipodystrophy. Further studies are needed to dissect the factors that mediate lipoatrophy in HIV infection.",

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AU - Kotler, Donald P.

AU - Ionescu, Gabriel

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AU - Inada, Yori

AU - He, Qing

AU - Engelson, Ellen S.

AU - Albu, Jeanine B.

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AB - We studied aspects of metabolism in subcutaneous adipose tissue (SAT) in 40 human immunodeficiency virus (HIV)-infected subjects with and without lipodystrophy and in healthy control subjects. HIV-infected subjects without lipodystrophy had less SAT and visceral adipose tissue (VAT). Glycerol release was higher in both HIV-infected groups, especially those without fat redistribution. Tumor necrosis factor (TNF) release from SAT and serum soluble TNF receptor 2 concentrations were significantly higher in HIV-infected individuals with lipodystrophy. The absolute production of acylation-stimulating protein (ASP) and the percentage conversion of the complement protein to ASP were significantly lower in HIV-infected subjects with lipodystrophy. Further studies are needed to dissect the factors that mediate lipoatrophy in HIV infection.

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Studies of adipose tissue metabolism in human immunodeficiency virus - Associated lipodystrophy

Abstract

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