TY - JOUR
T1 - Stuck in a rut
T2 - Rethinking depression and its treatment
AU - Holtzheimer, Paul E.
AU - Mayberg, Helen S.
N1 - Funding Information:
P.E.H. has received grant funding from the Dana Foundation, Greenwall Foundation, NARSAD, NIMH (K23 MH077869), National Institutes of Health Loan Repayment Program, Northstar, Inc., Stanley Medical Research Institute, and Woodruff Foundation; he has received consulting fees from AvaCat Consulting, St Jude Medical Neuromodulation and Oppenheimer & Co. H.S.M. has a consulting agreement with St Jude Medical Inc., which has licensed her intellectual property to develop SCC DBS for the treatment of severe depression. H.S.M. has received grant funding from the Dana Foundation, NARSAD, National Institute of Mental Health (NIMH), Stanley Medical Research Institute, and Woodruff Foundation.
PY - 2011/1
Y1 - 2011/1
N2 - The current definition of major depressive disorder (MDD) emerged from efforts to create reliable diagnostic criteria for clinical and research use. However, despite decades of research, the neurobiology of MDD is largely unknown, and treatments are no more effective today than they were 50-70 years ago. Here, we propose that the current conception of depression is misguiding basic and clinical research. Redefinition is necessary and could include a focus on a more narrowly defined set of core symptoms. However, we conclude that depression is better defined as the tendency to enter into, and inability to disengage from, a negative mood state rather than the mood state per se. We also discuss the implications of this revised definition for future clinical and basic research.
AB - The current definition of major depressive disorder (MDD) emerged from efforts to create reliable diagnostic criteria for clinical and research use. However, despite decades of research, the neurobiology of MDD is largely unknown, and treatments are no more effective today than they were 50-70 years ago. Here, we propose that the current conception of depression is misguiding basic and clinical research. Redefinition is necessary and could include a focus on a more narrowly defined set of core symptoms. However, we conclude that depression is better defined as the tendency to enter into, and inability to disengage from, a negative mood state rather than the mood state per se. We also discuss the implications of this revised definition for future clinical and basic research.
UR - http://www.scopus.com/inward/record.url?scp=78650727581&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2010.10.004
DO - 10.1016/j.tins.2010.10.004
M3 - Short survey
C2 - 21067824
AN - SCOPUS:78650727581
SN - 0166-2236
VL - 34
SP - 1
EP - 9
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 1
ER -