@article{39c3ecf8157e465985c4a7294e31be49,
title = "Structures of NS5 Methyltransferase from Zika Virus",
abstract = "The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM and 7-methyl guanosine diphosphate (7-MeGpp). We identify features of ZIKV NS5 methyltransferase that lend to structure-based antiviral drug discovery. Specifically, SAM analogs with functionalities on the Cβ atom of the methionine portion of the molecules that occupy the RNA binding tunnel may provide better specificity relative to human RNA methyltransferases.",
author = "Javier Coloma and Rinku Jain and Rajashankar, {Kanagalaghatta R.} and Adolfo Garc{\'i}a-Sastre and Aggarwal, {Aneel K.}",
note = "Funding Information: We thank Jian Jin for helpful discussions. This work is based upon research conducted at the Northeastern Collaborative Access Team (NECAT) and GM/CA@APS beamlines at the Argonne National Laboratory. The NECAT beamlines are funded by the National Institute of General Medical Sciences (NIGMS) from the NIH ( P41 GM103403 ). The GM/CA@APS beamlines have been funded in whole or in part with funds from the National Cancer Institute ( ACB-12002 ) and NIGMS ( AGM-12006 ). The Pilatus 6M detector on 24-ID-C beam line is funded by an NIH-ORIP HEI grant ( S10 RR029205 ). This research used resources of the Advanced Photon Source, a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under contract no. DE-AC02-06CH11357 . A.G.-S. is partly supported by NIH grant U19AI118610 . Publisher Copyright: {\textcopyright} 2016 The Author(s)",
year = "2016",
month = sep,
day = "20",
doi = "10.1016/j.celrep.2016.08.091",
language = "English",
volume = "16",
pages = "3097--3102",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "12",
}