Structure of the NS3 helicase from Zika virus

Rinku Jain; Javier Coloma; Adolfo García-Sastre; Aneel K. Aggarwal

doi:10.1038/nsmb.3258

Structure of the NS3 helicase from Zika virus

Rinku Jain, Javier Coloma, Adolfo García-Sastre, Aneel K. Aggarwal

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Abstract

Zika virus has emerged as a pathogen of major health concern. Here, we present a high-resolution (1.62-Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in binding ATP and RNA. We identify druggable 'hotspots' that are well suited for in silico and/or fragment-based high-throughput drug discovery.

Original language	English
Pages (from-to)	752-754
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	23
Issue number	8
DOIs	https://doi.org/10.1038/nsmb.3258
State	Published - 1 Aug 2016

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AB - Zika virus has emerged as a pathogen of major health concern. Here, we present a high-resolution (1.62-Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in binding ATP and RNA. We identify druggable 'hotspots' that are well suited for in silico and/or fragment-based high-throughput drug discovery.

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Structure of the NS3 helicase from Zika virus

Abstract

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