Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis

Jing Hou, Kamila Wojciechowska, Heping Zheng, Maksymilian Chruszcz, David R. Cooper, Marcin Cymborowski, Tatiana Skarina, Elena Gordon, Haibin Luo, Alexei Savchenko, Wladek Minor

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The crystal structure of a short-chain dehydrogenase/reductase from Bacillus anthracis strain Ames Ancestor complexed with NADP has been determined and refined to 1.87 Å resolution. The structure of the enzyme consists of a Rossmann fold composed of seven parallel Β-strands sandwiched by three - helices on each side. An NADP molecule from an endogenous source is bound in the conserved binding pocket in the syn conformation. The loop region responsible for binding another substrate forms two perpendicular short helices connected by a sharp turn.

Original languageEnglish
Pages (from-to)632-637
Number of pages6
JournalActa Crystallographica Section F: Structural Biology and Crystallization Communications
Volume68
Issue number6
DOIs
StatePublished - May 2012
Externally publishedYes

Keywords

  • Bacillus anthracis
  • NADP
  • short-chain dehydrogenases/reductases

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