Structure-guided design of a high-affinity platelet integrin α IIbβ 3 receptor antagonist that disrupts Mg 2+ binding to the MIDAS

Jieqing Zhu, Won Seok Choi, Joshua G. McCoy, Ana Negri, Jianghai Zhu, Sarasija Naini, Jihong Li, Min Shen, Wenwei Huang, Daniel Bougie, Mark Rasmussen, Richard Aster, Craig J. Thomas, Marta Filizola, Timothy A. Springer, Barry S. Coller

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Biochemistry, Genetics and Molecular Biology

Pharmacology, Toxicology and Pharmaceutical Science