Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design

Susan Zolla-Pazner, Timothy Cardozo

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations

Abstract

One of the main challenges of developing an HIV-1 vaccine lies in eliciting immune responses that can overcome the antigenic variability exhibited by HIV. Most HIV-1 vaccine development has focused on inducing immunity to conserved regions of the HIV-1 envelope. However, new studies of the sequence-variable regions of the HIV-1 gp120 envelope glycoprotein have shown that there are conserved immunological and structural features in these regions. Recombinant immunogens that include these features may provide the means to address the antigenic diversity of HIV-1 and induce protective antibodies that can prevent infection with HIV-1.

Original languageEnglish
Pages (from-to)527-535
Number of pages9
JournalNature Reviews Immunology
Volume10
Issue number7
DOIs
StatePublished - Jul 2010
Externally publishedYes

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