Structure and bioactivity of sulfated polysaccharides

Toshihiko Toida, Amornrut Chaidedgumjorn, Robert J. Linhardt

Research output: Contribution to journalShort surveypeer-review

70 Scopus citations

Abstract

Sulfated polysaccharides including glycosaminoglycans show various chemical and biological functions. These functions strongly depend on the presence and spatial positioning of their sulfo groups. Therefore, chemical modifications such as partial, per-O-sulfonation or desulfonation are expected to alter the function of sulfated polysaccharides. There are many reports on the chemical modification of polysaccharides. This paper focuses on the investigation of both the chemical modification of polysaccharides and its effect biological function. A structure-activity relationship, SAR, is established on both intact and chemically modified polysaccharides.

Original languageEnglish
Pages (from-to)29-46
Number of pages18
JournalTrends in Glycoscience and Glycotechnology
Volume15
Issue number81
DOIs
StatePublished - Jan 2003
Externally publishedYes

Keywords

  • Anti-HAase activity
  • Anti-coagulant activity
  • Chemical O-sulfonation
  • Molecular weight
  • Sulfated polysaccharides

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