Structural signatures: A web server for exploring a database of and generating protein structural features from human cell lines and tissues

Nicole Zatorski, David Stein, Rayees Rahman, Ravi Iyengar, Avner Schlessinger

Research output: Contribution to journalArticlepeer-review

Abstract

Structural features of proteins provide powerful insights into biological function and similarity. Specifically, previous work has demonstrated that structural features of tissue and drug-treated cell line samples can be used to predict tissue type and characterize drug relationships, respectively. We have developed structural signatures, a web server for annotating and analyzing protein features from gene sets that are often found in transcriptomic and proteomic data. This platform provides access to a structural feature database derived from normal and disease human tissue samples. We show how analysis using this database can shed light on the relationship between states of single-cell RNA-sequencing lung cancer samples. These various structural feature signatures can be visualized on the server itself or downloaded for additional analysis. The structural signatures server tool is freely available at https://structural-server.kinametrix.com/.

Original languageEnglish
Article numberbaac053
JournalDatabase : the journal of biological databases and curation
Volume2022
DOIs
StatePublished - 2022

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