Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1

Barbara A. Hendrickson; Wei Zhang; Robert J. Craig; Jin Yong-Jiu; Barbara E. Bierer; Steven Burakoff; Anthony G. DiLella

doi:10.1016/0378-1119(93)90106-D

Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1

Barbara A. Hendrickson, Wei Zhang, Robert J. Craig, Jin Yong-Jiu, Barbara E. Bierer, Steven Burakoff, Anthony G. DiLella

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

FK506-binding protein (FKBP) 12 and FKBP13 are members of a family of proteins which bind the immuno-suppressant drugs, FK506 and rapamycin. FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized. We now report the genomic structure of the human and murine FKBP2 genes. Comparison of FKBP1 and FKBP2 reveals significant homology and correlation of intron positions in the C-terminal region, suggesting that these genes may have evolved from a common ancestral gene.

Original language	English
Pages (from-to)	271-275
Number of pages	5
Journal	Gene
Volume	134
Issue number	2
DOIs	https://doi.org/10.1016/0378-1119(93)90106-D
State	Published - 8 Dec 1993
Externally published	Yes

Keywords

Immunosuppressant
genomic library
immunophilin
rapamycin
recombinant DNA

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10.1016/0378-1119(93)90106-D

Cite this

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title = "Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1",

abstract = "FK506-binding protein (FKBP) 12 and FKBP13 are members of a family of proteins which bind the immuno-suppressant drugs, FK506 and rapamycin. FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized. We now report the genomic structure of the human and murine FKBP2 genes. Comparison of FKBP1 and FKBP2 reveals significant homology and correlation of intron positions in the C-terminal region, suggesting that these genes may have evolved from a common ancestral gene.",

keywords = "Immunosuppressant, genomic library, immunophilin, rapamycin, recombinant DNA",

author = "Hendrickson, {Barbara A.} and Wei Zhang and Craig, {Robert J.} and Jin Yong-Jiu and Bierer, {Barbara E.} and Steven Burakoff and DiLella, {Anthony G.}",

note = "Funding Information: B.A.H. is supported by a NIAID Physician Scientist Award. W.Z. is a Howard Hughes Medical Institute predoctoral fellow. This work was supported in part by awards from the Howard Hughes Medical Institute and the National Institutes of Health.",

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doi = "10.1016/0378-1119(93)90106-D",

language = "English",

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journal = "Gene",

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T1 - Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1

AU - Hendrickson, Barbara A.

AU - Zhang, Wei

AU - Craig, Robert J.

AU - Yong-Jiu, Jin

AU - Bierer, Barbara E.

AU - Burakoff, Steven

AU - DiLella, Anthony G.

N1 - Funding Information: B.A.H. is supported by a NIAID Physician Scientist Award. W.Z. is a Howard Hughes Medical Institute predoctoral fellow. This work was supported in part by awards from the Howard Hughes Medical Institute and the National Institutes of Health.

PY - 1993/12/8

Y1 - 1993/12/8

N2 - FK506-binding protein (FKBP) 12 and FKBP13 are members of a family of proteins which bind the immuno-suppressant drugs, FK506 and rapamycin. FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized. We now report the genomic structure of the human and murine FKBP2 genes. Comparison of FKBP1 and FKBP2 reveals significant homology and correlation of intron positions in the C-terminal region, suggesting that these genes may have evolved from a common ancestral gene.

AB - FK506-binding protein (FKBP) 12 and FKBP13 are members of a family of proteins which bind the immuno-suppressant drugs, FK506 and rapamycin. FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized. We now report the genomic structure of the human and murine FKBP2 genes. Comparison of FKBP1 and FKBP2 reveals significant homology and correlation of intron positions in the C-terminal region, suggesting that these genes may have evolved from a common ancestral gene.

KW - Immunosuppressant

KW - genomic library

KW - immunophilin

KW - rapamycin

KW - recombinant DNA

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EP - 275

JO - Gene

JF - Gene

IS - 2

ER -

Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1

Abstract

Keywords

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