Abstract
The evolutionarily-conserved eukaryotic SMC (structural maintenance of chromosomes) proteins are ubiquitous chromosomal components in prokaryotes and eukaryotes. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. The two most prominent and best-characterized complexes are cohesin and condensin, necessary for sister chromatid cohesion and chromosome condensation. Here we discuss these functions together with additional roles in gene dosage compensation and DNA recombination.
| Original language | English |
|---|---|
| Pages (from-to) | 6-13 |
| Number of pages | 8 |
| Journal | European Journal of Biochemistry |
| Volume | 263 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jul 1999 |
| Externally published | Yes |
Keywords
- Cell cycle
- Chromatin dynamics
- Chromosome condensation
- DNA recombination
- Gene dosage compensation
- SMC proteins
- Sister chromatid cohesion
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