Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis

ENIGMA-Anxiety Working Group

doi:10.1016/j.jaac.2022.04.023

Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis

ENIGMA-Anxiety Working Group

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Original language	English
Pages (from-to)	1182-1188
Number of pages	7
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	61
Issue number	9
DOIs	https://doi.org/10.1016/j.jaac.2022.04.023
State	Published - Sep 2022
Externally published	Yes

Access to Document

10.1016/j.jaac.2022.04.023

Cite this

@article{6c971e64547b4becb04c767eb130fed6,

title = "Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis",

author = "\{ENIGMA-Anxiety Working Group\} and Bas-Hoogendam, \{Janna Marie\} and Rachel Bernstein and Benson, \{Brenda E.\} and Buss, \{Kristin A.\} and Gunther, \{Kelley E.\} and Koraly P{\'e}rez-Edgar and Salum, \{Giovanni A.\} and Jackowski, \{Andrea P.\} and Bressan, \{Rodrigo A.\} and Andr{\'e} Zugman and Degnan, \{Kathryn A.\} and Filippi, \{Courtney A.\} and Fox, \{Nathan A.\} and Henderson, \{Heather A.\} and Alva Tang and Selin Zeytinoglu and Anita Harrewijn and Hillegers, \{Manon H.J.\} and Tonya White and \{van IJzendoorn\}, \{Marinus H.\} and Schwartz, \{Carl E.\} and Felicione, \{Julia M.\} and DeYoung, \{Kathryn A.\} and Shackman, \{Alexander J.\} and Smith, \{Jason F.\} and Tillman, \{Rachael M.\} and \{van den Berg\}, \{Yvonne H.M.\} and Cillessen, \{Antonius H.N.\} and Karin Roelofs and Anna Tyborowska and Hill, \{Shirley Y.\} and Marco Battaglia and Marco Tettamanti and Dougherty, \{Lea R.\} and Jingwen Jin and Klein, \{Daniel N.\} and Leung, \{Hoi Chung\} and Avery, \{Suzanne N.\} and Blackford, \{Jennifer Urbano\} and Clauss, \{Jacqueline A.\} and Hayden, \{Elizabeth P.\} and Pan Liu and Vandermeer, \{Matthew R.J.\} and Goldsmith, \{H. Hill\} and Planalp, \{Elizabeth M.\} and Nichols, \{Thomas E.\} and Thompson, \{Paul M.\} and Westenberg, \{P. Michiel\} and \{van der Wee\}, \{Nic J.A.\} and Stein, \{Dan J.\}",

note = "Funding Information: Disclosure: Dr. P{\'e}rez-Edgar has received funding from the National Institute on Drug Abuse (U01DA055361-01) and NIMH (R56MH126349, R01MH109692, and R01MH130007); royalties from Springer Press; and honoraria for lectures to professional audiences and for editing Developmental Psychology. Dr. Salum has reported that the Brazilian High-Risk Cohort for Mental Conditions was supported with grants from the National Institute of Developmental Psychiatry for Children and Adolescents (INPD), the Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq; 465550/2014-2), and the S{\~a}o Paulo Research Foundation (2014/50917-0). Dr. Jackowski has received grant support from CNPq 427215/2018-8. Dr. Degnan has received grant support from a subaward from NIMH (U01MH093349) via the University of Maryland and honoraria for associate editor duties with Developmental Psychology. Dr. Filippi has received a NARSAD Young Investigator Grant from the Brain and Behavior Foundation (\#28024) and the Intramural Research Program of NIMH through project ZIA-MH-002782. Dr. Fox has received grant support from NIMH (U01MH093349), NICHD, the National Science Foundation (NSF), the National Institutes of Health Environmental influences on Child Health Outcomes (NIH ECHO) consortium, the Russell Sage Foundation, and the Lumos Foundation; royalties from Springer Press, Guilford Press, and Harvard University Press; and honoraria for lectures to professional audiences. Dr. Henderson has received grant support from the Social Sciences and Humanities Research Council of Canada and the Canada Foundation for Innovation. Dr. White has received grant or research support from the Sophia Children{\textquoteright}s Hospital Foundation. She has served on the advisory board/Data Safety and Monitoring Board of the University of Bergen Center for Brain Plasticity. She has served on the editorial board of Neuroinformatics and as Editor-in-Chief of Aperture Neuro. Drs. Roelofs and Tyborowska have reported that past magnetic resonance imaging scanning of the Nijmegen Longitudinal Study (NLS) was funded by European Research Council starting grant (ERC\_StG2012\_313749 awarded to K.R.) and a FP7-HEALTH-2013-INNOVATION grant (602805-2). Dr. Hill has received grant support from the National Institute on Alcohol Abuse and Alcoholism (AA021746 and AA021746-05S1-Supplement). Dr. Thompson has received partial research support from Biogen, Inc., unrelated to this work, and NIH Big Data to Knowledge (BD2K) award (U54 EB020403). Dr. van der Wee has received grant support from the EU Innovative Medicines Initiative Psychiatric Ratings using Intermediate Stratified Markers 2 (IMI PRISM 2) with grant agreement number 101034377. Dr. Stein has received research grants and/or consultancy honoraria from Discovery Vitality, Johnson \& Johnson, Kanna, Lundbeck, Orion, Sanofi, Servier, and Takeda. Ms. Gunther has received an NSF Graduate Research Fellowship (DGE1255832). Drs. Bas-Hoogendam, Benson, Buss, Bressan, Zugman, Tang, Zeytinoglu, Harrewijn, Hillegers, van IJzendoorn, Schwartz, Shackman, Smith, Tillman, van den Berg, Cillessen, Battaglia, Tettamanti, Dougherty, Jin, Klein, Leung, Avery, Blackford, Clauss, Hayden, Liu, Vandermeer, Goldsmith, Planalp, Nichols, Westenberg, Groenewold, Winkler, and Pine and Mss. Bernstein, Felicione, and DeYoung have reported no biomedical financial interests or potential conflicts of interest. Funding Information: This project is funded by a Rubicon grant from the Dutch Research Council NWO ( 019.201SG.022 ), awarded to Janna Marie Bas-Hoogendam. Other funding related to the content of the manuscript: Rachel Bernstein, Brenda E. Benson, Andr{\'e} Zugman, Anderson M. Winkler, and Daniel S. Pine: the National Institute of Mental Health (NIMH) Intramural Research Program Project ZIAMH002782. Kristin A. Buss: NIMH R01MH094633S1. Koraly P{\'e}rez-Edgar: NIMH R01MH094633 and NIMH R01MH094633S1. Kathryn A. Degnan, Nathan A. Fox, and Heather A. Henderson: NIMH U01MH093349. Anita Harrewijn: European Union{\textquoteright}s Horizon 2020 Research and Innovation Programme under the Marie Sk{\l}odowska-Curie grant agreement No 101026595. Carl E. Schwartz: NIMH Career Development Award, the National Institutes of Health (NIH)/NIMH R01MH07484 , and NIH/NIMH R01MH071467 . Alexander J. Shackman: NIMH R01MH107444 and NIMH R01MH121409. Karin Roelofs: European Research Council (ERC\_CoG-2017\_772337). Shirley Y. Hill: past grant support (AA05909, AA08082, and AA018289). Lea R. Dougherty: NIMH R01MH122487 and NIMH R01MH121385. Daniel N. Klein: NIMH RO1MH069942. Jennifer Urbano Blackford: NIMH K01MH083052. Jacqueline A. Clauss: F30MH097344. Elizabeth P. Hayden: BrainsCAN initiative at Western University funded by the Canada First Research Excellence Fund ( CFREF ). Matthew R.J. Vandermeer: Canadian Institutes for Health Research (CIHR) Frederick Banting \& Charles Best Canada Graduate Scholarships Doctoral Award. H. Hill Goldsmith: NIMH R01MH101504 and NIMH R01MH059785 ; infrastructure support by the Waisman Center via core support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD; P30 HD003352 and U54 HD090256 ). Elizabeth M. Planalp: NIMH K01MH113710. Paul M. Thompson: NIMH grants R01MH116147 , R01MH121246 , R01MH123163 , the Milken Foundation, and the Baszucki Brain Research Fund. P. Michiel Westenberg: supported by Leiden University Research Profile Health, Prevention, and the Human Life Cycle. Nynke A. Groenewold: this work was made possible in part by a grant from Carnegie Corporation of New York . The statements made and views expressed are solely the responsibility of the author; Dan J. Stein, funded by the South African Medical Research Council . Funding Information: This project is funded by a Rubicon grant from the Dutch Research Council NWO (019.201SG.022), awarded to Janna Marie Bas-Hoogendam. Other funding related to the content of the manuscript: Rachel Bernstein, Brenda E. Benson, Andr{\'e} Zugman, Anderson M. Winkler, and Daniel S. Pine: the National Institute of Mental Health (NIMH) Intramural Research Program Project ZIAMH002782. Kristin A. Buss: NIMH R01MH094633S1. Koraly P{\'e}rez-Edgar: NIMH R01MH094633 and NIMH R01MH094633S1. Kathryn A. Degnan, Nathan A. Fox, and Heather A. Henderson: NIMH U01MH093349. Anita Harrewijn: European Union's Horizon 2020 Research and Innovation Programme under the Marie Sk{\l}odowska-Curie grant agreement No 101026595. Carl E. Schwartz: NIMH Career Development Award, the National Institutes of Health (NIH)/NIMH R01MH07484, and NIH/NIMH R01MH071467. Alexander J. Shackman: NIMH R01MH107444 and NIMH R01MH121409. Karin Roelofs: European Research Council (ERC\_CoG-2017\_772337). Shirley Y. Hill: past grant support (AA05909, AA08082, and AA018289). Lea R. Dougherty: NIMH R01MH122487 and NIMH R01MH121385. Daniel N. Klein: NIMH RO1MH069942. Jennifer Urbano Blackford: NIMH K01MH083052. Jacqueline A. Clauss: F30MH097344. Elizabeth P. Hayden: BrainsCAN initiative at Western University funded by the Canada First Research Excellence Fund (CFREF). Matthew R.J. Vandermeer: Canadian Institutes for Health Research (CIHR) Frederick Banting \& Charles Best Canada Graduate Scholarships Doctoral Award. H. Hill Goldsmith: NIMH R01MH101504 and NIMH R01MH059785; infrastructure support by the Waisman Center via core support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD; P30 HD003352 and U54 HD090256). Elizabeth M. Planalp: NIMH K01MH113710. Paul M. Thompson: NIMH grants R01MH116147, R01MH121246, R01MH123163, the Milken Foundation, and the Baszucki Brain Research Fund. P. Michiel Westenberg: supported by Leiden University Research Profile Health, Prevention, and the Human Life Cycle. Nynke A. Groenewold: this work was made possible in part by a grant from Carnegie Corporation of New York. The statements made and views expressed are solely the responsibility of the author; Dan J. Stein, funded by the South African Medical Research Council.",

year = "2022",

month = sep,

doi = "10.1016/j.jaac.2022.04.023",

language = "English",

volume = "61",

pages = "1182--1188",

journal = "Journal of the American Academy of Child and Adolescent Psychiatry",

issn = "0890-8567",

publisher = "Elsevier Inc.",

number = "9",

}

TY - JOUR

T1 - Structural Brain Correlates of Childhood Inhibited Temperament

T2 - An ENIGMA-Anxiety Mega-analysis

AU - ENIGMA-Anxiety Working Group

AU - Bas-Hoogendam, Janna Marie

AU - Bernstein, Rachel

AU - Benson, Brenda E.

AU - Buss, Kristin A.

AU - Gunther, Kelley E.

AU - Pérez-Edgar, Koraly

AU - Salum, Giovanni A.

AU - Jackowski, Andrea P.

AU - Bressan, Rodrigo A.

AU - Zugman, André

AU - Degnan, Kathryn A.

AU - Filippi, Courtney A.

AU - Fox, Nathan A.

AU - Henderson, Heather A.

AU - Tang, Alva

AU - Zeytinoglu, Selin

AU - Harrewijn, Anita

AU - Hillegers, Manon H.J.

AU - White, Tonya

AU - van IJzendoorn, Marinus H.

AU - Schwartz, Carl E.

AU - Felicione, Julia M.

AU - DeYoung, Kathryn A.

AU - Shackman, Alexander J.

AU - Smith, Jason F.

AU - Tillman, Rachael M.

AU - van den Berg, Yvonne H.M.

AU - Cillessen, Antonius H.N.

AU - Roelofs, Karin

AU - Tyborowska, Anna

AU - Hill, Shirley Y.

AU - Battaglia, Marco

AU - Tettamanti, Marco

AU - Dougherty, Lea R.

AU - Jin, Jingwen

AU - Klein, Daniel N.

AU - Leung, Hoi Chung

AU - Avery, Suzanne N.

AU - Blackford, Jennifer Urbano

AU - Clauss, Jacqueline A.

AU - Hayden, Elizabeth P.

AU - Liu, Pan

AU - Vandermeer, Matthew R.J.

AU - Goldsmith, H. Hill

AU - Planalp, Elizabeth M.

AU - Nichols, Thomas E.

AU - Thompson, Paul M.

AU - Westenberg, P. Michiel

AU - van der Wee, Nic J.A.

AU - Stein, Dan J.

N1 - Funding Information: Disclosure: Dr. Pérez-Edgar has received funding from the National Institute on Drug Abuse (U01DA055361-01) and NIMH (R56MH126349, R01MH109692, and R01MH130007); royalties from Springer Press; and honoraria for lectures to professional audiences and for editing Developmental Psychology. Dr. Salum has reported that the Brazilian High-Risk Cohort for Mental Conditions was supported with grants from the National Institute of Developmental Psychiatry for Children and Adolescents (INPD), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; 465550/2014-2), and the São Paulo Research Foundation (2014/50917-0). Dr. Jackowski has received grant support from CNPq 427215/2018-8. Dr. Degnan has received grant support from a subaward from NIMH (U01MH093349) via the University of Maryland and honoraria for associate editor duties with Developmental Psychology. Dr. Filippi has received a NARSAD Young Investigator Grant from the Brain and Behavior Foundation (#28024) and the Intramural Research Program of NIMH through project ZIA-MH-002782. Dr. Fox has received grant support from NIMH (U01MH093349), NICHD, the National Science Foundation (NSF), the National Institutes of Health Environmental influences on Child Health Outcomes (NIH ECHO) consortium, the Russell Sage Foundation, and the Lumos Foundation; royalties from Springer Press, Guilford Press, and Harvard University Press; and honoraria for lectures to professional audiences. Dr. Henderson has received grant support from the Social Sciences and Humanities Research Council of Canada and the Canada Foundation for Innovation. Dr. White has received grant or research support from the Sophia Children’s Hospital Foundation. She has served on the advisory board/Data Safety and Monitoring Board of the University of Bergen Center for Brain Plasticity. She has served on the editorial board of Neuroinformatics and as Editor-in-Chief of Aperture Neuro. Drs. Roelofs and Tyborowska have reported that past magnetic resonance imaging scanning of the Nijmegen Longitudinal Study (NLS) was funded by European Research Council starting grant (ERC_StG2012_313749 awarded to K.R.) and a FP7-HEALTH-2013-INNOVATION grant (602805-2). Dr. Hill has received grant support from the National Institute on Alcohol Abuse and Alcoholism (AA021746 and AA021746-05S1-Supplement). Dr. Thompson has received partial research support from Biogen, Inc., unrelated to this work, and NIH Big Data to Knowledge (BD2K) award (U54 EB020403). Dr. van der Wee has received grant support from the EU Innovative Medicines Initiative Psychiatric Ratings using Intermediate Stratified Markers 2 (IMI PRISM 2) with grant agreement number 101034377. Dr. Stein has received research grants and/or consultancy honoraria from Discovery Vitality, Johnson & Johnson, Kanna, Lundbeck, Orion, Sanofi, Servier, and Takeda. Ms. Gunther has received an NSF Graduate Research Fellowship (DGE1255832). Drs. Bas-Hoogendam, Benson, Buss, Bressan, Zugman, Tang, Zeytinoglu, Harrewijn, Hillegers, van IJzendoorn, Schwartz, Shackman, Smith, Tillman, van den Berg, Cillessen, Battaglia, Tettamanti, Dougherty, Jin, Klein, Leung, Avery, Blackford, Clauss, Hayden, Liu, Vandermeer, Goldsmith, Planalp, Nichols, Westenberg, Groenewold, Winkler, and Pine and Mss. Bernstein, Felicione, and DeYoung have reported no biomedical financial interests or potential conflicts of interest. Funding Information: This project is funded by a Rubicon grant from the Dutch Research Council NWO ( 019.201SG.022 ), awarded to Janna Marie Bas-Hoogendam. Other funding related to the content of the manuscript: Rachel Bernstein, Brenda E. Benson, André Zugman, Anderson M. Winkler, and Daniel S. Pine: the National Institute of Mental Health (NIMH) Intramural Research Program Project ZIAMH002782. Kristin A. Buss: NIMH R01MH094633S1. Koraly Pérez-Edgar: NIMH R01MH094633 and NIMH R01MH094633S1. Kathryn A. Degnan, Nathan A. Fox, and Heather A. Henderson: NIMH U01MH093349. Anita Harrewijn: European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement No 101026595. Carl E. Schwartz: NIMH Career Development Award, the National Institutes of Health (NIH)/NIMH R01MH07484 , and NIH/NIMH R01MH071467 . Alexander J. Shackman: NIMH R01MH107444 and NIMH R01MH121409. Karin Roelofs: European Research Council (ERC_CoG-2017_772337). Shirley Y. Hill: past grant support (AA05909, AA08082, and AA018289). Lea R. Dougherty: NIMH R01MH122487 and NIMH R01MH121385. Daniel N. Klein: NIMH RO1MH069942. Jennifer Urbano Blackford: NIMH K01MH083052. Jacqueline A. Clauss: F30MH097344. Elizabeth P. Hayden: BrainsCAN initiative at Western University funded by the Canada First Research Excellence Fund ( CFREF ). Matthew R.J. Vandermeer: Canadian Institutes for Health Research (CIHR) Frederick Banting & Charles Best Canada Graduate Scholarships Doctoral Award. H. Hill Goldsmith: NIMH R01MH101504 and NIMH R01MH059785 ; infrastructure support by the Waisman Center via core support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD; P30 HD003352 and U54 HD090256 ). Elizabeth M. Planalp: NIMH K01MH113710. Paul M. Thompson: NIMH grants R01MH116147 , R01MH121246 , R01MH123163 , the Milken Foundation, and the Baszucki Brain Research Fund. P. Michiel Westenberg: supported by Leiden University Research Profile Health, Prevention, and the Human Life Cycle. Nynke A. Groenewold: this work was made possible in part by a grant from Carnegie Corporation of New York . The statements made and views expressed are solely the responsibility of the author; Dan J. Stein, funded by the South African Medical Research Council . Funding Information: This project is funded by a Rubicon grant from the Dutch Research Council NWO (019.201SG.022), awarded to Janna Marie Bas-Hoogendam. Other funding related to the content of the manuscript: Rachel Bernstein, Brenda E. Benson, André Zugman, Anderson M. Winkler, and Daniel S. Pine: the National Institute of Mental Health (NIMH) Intramural Research Program Project ZIAMH002782. Kristin A. Buss: NIMH R01MH094633S1. Koraly Pérez-Edgar: NIMH R01MH094633 and NIMH R01MH094633S1. Kathryn A. Degnan, Nathan A. Fox, and Heather A. Henderson: NIMH U01MH093349. Anita Harrewijn: European Union's Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement No 101026595. Carl E. Schwartz: NIMH Career Development Award, the National Institutes of Health (NIH)/NIMH R01MH07484, and NIH/NIMH R01MH071467. Alexander J. Shackman: NIMH R01MH107444 and NIMH R01MH121409. Karin Roelofs: European Research Council (ERC_CoG-2017_772337). Shirley Y. Hill: past grant support (AA05909, AA08082, and AA018289). Lea R. Dougherty: NIMH R01MH122487 and NIMH R01MH121385. Daniel N. Klein: NIMH RO1MH069942. Jennifer Urbano Blackford: NIMH K01MH083052. Jacqueline A. Clauss: F30MH097344. Elizabeth P. Hayden: BrainsCAN initiative at Western University funded by the Canada First Research Excellence Fund (CFREF). Matthew R.J. Vandermeer: Canadian Institutes for Health Research (CIHR) Frederick Banting & Charles Best Canada Graduate Scholarships Doctoral Award. H. Hill Goldsmith: NIMH R01MH101504 and NIMH R01MH059785; infrastructure support by the Waisman Center via core support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD; P30 HD003352 and U54 HD090256). Elizabeth M. Planalp: NIMH K01MH113710. Paul M. Thompson: NIMH grants R01MH116147, R01MH121246, R01MH123163, the Milken Foundation, and the Baszucki Brain Research Fund. P. Michiel Westenberg: supported by Leiden University Research Profile Health, Prevention, and the Human Life Cycle. Nynke A. Groenewold: this work was made possible in part by a grant from Carnegie Corporation of New York. The statements made and views expressed are solely the responsibility of the author; Dan J. Stein, funded by the South African Medical Research Council.

PY - 2022/9

Y1 - 2022/9

UR - https://www.scopus.com/pages/publications/85133785665

U2 - 10.1016/j.jaac.2022.04.023

DO - 10.1016/j.jaac.2022.04.023

M3 - Article

AN - SCOPUS:85133785665

SN - 0890-8567

VL - 61

SP - 1182

EP - 1188

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

IS - 9

ER -