Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus

Rui Xu, Damian C. Ekiert, Jens C. Krause, Rong Hai, James E. Crowe, Ian A. Wilson

Research output: Contribution to journalArticlepeer-review

501 Scopus citations

Abstract

The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/Califomia/04/2009 HlNl virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human HlNl viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 HlNl viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalScience
Volume328
Issue number5976
DOIs
StatePublished - 16 Apr 2010
Externally publishedYes

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